002101 B6.129S2-<i>Trp53^tm1Tyj</i>/J <em>Trp53</em> knockout mutant mice develop tumors at three to six months of age. They are suitable for use in applications related to the study of familial breast cancers such as Li-Fraumeni syndrome as well as research of lung, brain and bone tumors, lymphoma and leukemia, and other rare cancers.

2025年2月18日 · TP53 haploinsufficiency completely rescues emergency granulopoiesis in FANCC (-/-) mice. P53 promotes retinoid acid-induced smooth muscle cell differentiation by targeting myocardin.

2013年1月14日 · Here, we review studies utilizing p53 mutant mice that have recapitulated and informed clinical observations. These studies have demonstrated the p53 contribution, sometimes beneficial and...

2025年2月11日 · This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute t...

View mouse Trp53 Chr11:69471185-69482699 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. This strain is a mouse model lacking Trp53, which is a gene homologous to human TP53. Homozygous Trp53-KO male mice develop normally but are prone to spontaneous tumors.

The TP53 gene encodes the tumor suppressor p53 which is functionally inactivated in many human cancers. Numerous studies suggested that 3′UTR-mediated p53 expression regulation plays a role in tumorigenesis and could be exploited for therapeutic ...

2009年9月24日 · Cell and molecular biological studies of p53 functions over the past 30 years have been complemented in the past 20 years by studies that use genetically engineered mice. As expected, mice that...

这个基因编码肿瘤蛋白p53，它可以响应多种细胞压力来调节诱导细胞周期停滞、凋亡、衰老、DNA修复或代谢变化的目标基因。 p53蛋白在正常细胞中表达水平较低，而在各种转化细胞系中表达水平较高，被认为有助于转化和恶性化。 p53是一种含有转录激活、DNA结合和寡聚化结构域的DNA结合蛋白。 它被认为结合到一个p53结合位点，并激活抑制生长和/或侵袭的下游基因的表达，从而起到肿瘤抑制因子的作用。 缺乏这个基因的小鼠在发育上是正常的，但容易患自发性 …

In the 10 years since the first knockout of the mouse p53 tumor suppressor gene (designated Trp53) was published, much has been learned about the contribution of p53 to biology and tumor suppression in the breast through the use of p53 transgenic and knockout mice.