2024年12月25日 · TRAF1 (TNF Receptor Associated Factor 1) is a Protein Coding gene. Diseases associated with TRAF1 include Anaplastic Large Cell Lymphoma and Rheumatoid Arthritis. Among its related pathways are TNFR1 Pathway and TNF signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and …

TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene. [5] The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily.

发现 EBV 感染膜蛋白 1 (LMP1) 与该蛋白和其他 TRAF 蛋白相互作用；这种相互作用被认为将 LMP1 介导的 B 淋巴细胞转化与 TNFR 家族受体的信号转导联系起来。 已发现该基因编码两种不同亚型的三种转录变体。 [RefSeq 提供，2010 年 7 月] The protein encoded by this gene is a member of the TNF Receptor (TNFR) associated factor (TRAF) protein family.

肿瘤坏死因子受体相关因子 (tumor necrosis factor receptor-associated factors, TRAF)是一类重要的具有多功能的细胞内信号转导因子。 TRAF参与多种受体家族的信号转导，包括肿瘤坏死因子受体家族 (tumor necrosis factor receptor, TNFR)和Toll样-IL-1受体 (Toll-like receptors-interleukin-1 receptors,TLR-IL-1R)家族等，在固有免疫和获得性免疫中发挥重要作用。 目前研究表明，TRAFs不仅仅是一个接头分子，它还可能作为一个调节分子发挥作用。 下面就来跟大家分 …

2016年5月6日 · TRAF1 is a unique family of TRAF lacking the N-terminal RING finger domain. TRAF1 is an important scaffold protein that participates in TNFR2 signaling in T cells as a negative or positive...

TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection. Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis.

2016年11月28日 · These findings reveal an unexpected role for TRAF1 in negatively regulating Toll-like receptor signaling, providing a mechanistic explanation for the increased inflammation seen with a disease ...

Tumor necrosis factor receptor (TNFR) associated factor 1 (TRAF1) is a signaling adaptor first identified as part of the TNFR2 signaling complex. TRAF1 plays a key role in pro-survival signaling downstream of TNFR superfamily members such as TNFR2, LMP1, 4-1BB, and CD40.

2018年12月18日 · Tumor necrosis factor receptor (TNFR) associated factor 1 (TRAF1) is a signaling adaptor first identified as part of the TNFR2 signaling complex. TRAF1 plays a key role in pro-survival signaling downstream of TNFR superfamily members such as TNFR2, LMP1, 4-1BB, and CD40. Recent studies have uncovere …

2024年4月23日 · This review presents an in-depth exploration of the current insights into the structural and molecular diversity exhibited by the TRAF domain and TRAF-binding motifs across a range of receptors, with a specific focus on TRAF1.