TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors.

2024年12月25日 · TRAF2 (TNF Receptor Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include Myeloma, Multiple and Hematologic Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

TRAF proteins associate with, and mediate the signal transduction from members of the TNF Receptor Superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/ JNK and NF-kappaB.

TRAF2 and TRAF5 therefore regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. The major pathways mediated by TRAF2 and TRAF5 are the classical and alternative pathways of NF-κB activation, and MAPK and JNK activation.

Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other signaling proteins, including plasma membrane receptors, kinases, phosphatases, other E3 ligases, and deubiquitinases.

2023年4月20日 · TRAF2 depletion inhibited growth and survival of liver cancer cells both in vitro and in vivo by causing p62 accumulation, which is partially rescued by simultaneous p62 knockdown....

肿瘤坏死因子受体相关因子 (tumor necrosis factor receptor-associated factors, TRAF)是一类重要的具有多功能的细胞内信号转导因子。 TRAF参与多种受体家族的信号转导，包括肿瘤坏死因子受体家族 (tumor necrosis factor receptor, TNFR)和Toll样-IL-1受体 (Toll-like receptors-interleukin-1 receptors,TLR-IL-1R)家族等，在固有免疫和获得性免疫中发挥重要作用。 目前研究表明，TRAFs不仅仅是一个接头分子，它还可能作为一个调节分子发挥作用。 下面就来跟大家分 …

2015年7月22日 · traf2可以调控下列复合物中成分间相互作. 用:tnf - r1 信号传导复合物( tnf - r1 - sc) 和. nf - κb 通路的i kk复合物,以及前者与c iap1 的. 相互作用. tnf - r1 - sc的解离伴有 tradd 的. 磷酸化,提示可能启动调控过程. 2. 2 traf2 是 tnf - r2 信号传导复合物的一部

2022年8月22日 · In this review, we summarize the various TRAF2-related signaling pathways and their relevance for the oncogenic and tumor suppressive activities of TRAF2. Particularly, we discuss currently emerging concepts to target TRAF2 for therapeutic purposes.

2024年1月8日 · traf2作为衔接蛋白和泛素e3连接酶，在介导tnfα-nfκb信号通路中发挥重要作用，并在多种人类癌症中表达失调，但traf2是否调节肝癌细胞的生长尚不清楚。