2024年12月25日 · TRAF5 (TNF Receptor Associated Factor 5) is a Protein Coding gene. Diseases associated with TRAF5 include Breast Cancer and Hematologic Cancer. Among its related pathways are BAFF in B-Cell Signaling and 4-1BB Pathway.

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene. [5] The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers.

该基因编码的支架蛋白是肿瘤坏死因子受体相关因子 (TRAF) 蛋白家族的成员，包含安眠蛋白和 TRAF 同源 (MATH) 结构域、一个 RING 型锌指和两个 TRAF 型锌指. TRAF 蛋白与 TNF 受体超家族成员相关并介导信号转导。 该蛋白是多蛋白复合物的成分之一，可与肿瘤坏死因子 (TNF) 受体胞质结构域结合并介导 TNF 诱导的激活。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2016 年 1 月]

2024年9月19日 · TRAF5 promotes the occurrence and development of colon cancer via the activation of PI3K/AKT/NF-κB signaling pathways. TNF receptor-associated factor 5 gene confers genetic predisposition to acute anterior uveitis and pediatric uveitis.

Evidence indicates that TRAF3 and TRAF5 play important roles beyond the TNFR-superfamily (SF) and viral mimics of its members, mediating certain innate immune receptor and cytokine receptor signals, and most recently, signals delivered …

TRAF5的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的支架蛋白是肿瘤坏死因子受体相关因子（TRAF）蛋白家族的一个成员，并含有一meprin和TRAF同源（数学）结构域，环型锌指和两个TRAF型锌指。

miR-141-3p and TRAF5 Network Contributes to the Progression of T-Cell Acute Lymphoblastic Leukemia. TRAF5 acts as a positive regulator of plasmacytoid DCs differentiation from bone marrow progenitors. miR-141-3p inhibited the proliferation, migration, and invasion via directly targeting tumor necrosis factor receptor-associated factor 5 (TRAF5).

1996年9月3日 · A cDNA encoding a putative signal transducer protein, designated TRAF5, has been molecularly cloned. TRAF5 has a tumor necrosis factor receptor-associated factor (TRAF) domain in its carboxyl terminus and is most homologous to TRAF3, also known as CRAF1, CD40bp, or LAP-1, a previously identified CD40-associated factor.

2024年9月24日 · traf5（肿瘤坏死因子受体相关因子5）是traf家族中的一员，广泛参与免疫调 控、细胞存活和炎症反应。 作为细胞信号转导的适配器蛋白，TRAF5主要通过与T

TRAF2 and TRAF5 therefore regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. The major pathways mediated by TRAF2 and TRAF5 are the classical and alternative pathways of NF-κB activation, and MAPK and JNK activation.