TREM1（Triggering receptor expressed on myeloid cells-1）是一种在中性粒细胞、单核细胞、巨噬细胞表面表达的 髓系细胞 触发受体。 TREM-1以两种形式存在：膜结合受体和可溶性蛋 …

trem-1选择性地表达于血液中性粒细胞和单核细胞，通过激活这些细胞，引起 白介素-8 （il-8）、 单核细胞趋化蛋白-1 （mcp-1）、 肿瘤坏死因子-α （tnf-α）等炎症前化学增活素的分泌，从 …

TREM1（Triggering receptor expressed on myeloid cells-1）是一种在中性粒细胞、单核细胞、巨噬细胞表面表达的髓系细胞表面受体，在多种肿瘤微环境中均表达，协同经典的 模式识别受 …

2023年2月7日 · Triggering receptors expressed on myeloid cells (TREMs) are a family of cell-surface receptors expressed broadly on myeloid cells. The first TREM identified, TREM1, was …

Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene.

2024年6月1日 · Over the past decade, there has been growing evidence for the involvement of TREM1 overactivation in tumor stroma inflammation and cancer progression. Indeed, it was …

人膜表面的TREM-1是一种234个氨基酸的I型跨膜蛋白，由一个细胞外免疫球蛋白（Ig）样结构域（184个氨基酸），一个带正电荷的赖氨酸残基的跨膜区和一个短的细胞质尾（5个氨基酸） …

2023年8月30日 · In this study, we describe PY159, a humanized, afucosylated, agonistic immunoglobulin G1κ (IgG1κ) antibody that specifically binds human TREM1. Because of its …

2023年8月31日 · To investigate the therapeutic potential of TREM1 in cancer, we used mice deficient in Trem1 and developed a novel small molecule TREM1 inhibitor, VJDT. We …

2021年7月19日 · Here, we aimed to decipher the molecular mechanisms and regulation of TREM-1 expression and sTREM-1 release with the objective of establishing a rationale for the use of …