
TREM1、TREM2丨髓系细胞表面受体的异军突起 - 知乎
TREM1(Triggering receptor expressed on myeloid cells-1)是一种在中性粒细胞、单核细胞、巨噬细胞表面表达的 髓系细胞 触发受体。 TREM-1以两种形式存在:膜结合受体和可溶性蛋 …
髓细胞触发受体1(TREM1) - 知乎 - 知乎专栏
trem-1选择性地表达于血液中性粒细胞和单核细胞,通过激活这些细胞,引起 白介素-8 (il-8)、 单核细胞趋化蛋白-1 (mcp-1)、 肿瘤坏死因子-α (tnf-α)等炎症前化学增活素的分泌,从 …
炎症和肿瘤免疫治疗领域新靶点:TREM1&TREM2 - 知乎
TREM1(Triggering receptor expressed on myeloid cells-1)是一种在中性粒细胞、单核细胞、巨噬细胞表面表达的髓系细胞表面受体,在多种肿瘤微环境中均表达,协同经典的 模式识别受 …
The biology of TREM receptors - Nature Reviews Immunology
2023年2月7日 · Triggering receptors expressed on myeloid cells (TREMs) are a family of cell-surface receptors expressed broadly on myeloid cells. The first TREM identified, TREM1, was …
TREM1 - Wikipedia
Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene.
TREM1: Activation, signaling, cancer and therapy - ScienceDirect
2024年6月1日 · Over the past decade, there has been growing evidence for the involvement of TREM1 overactivation in tumor stroma inflammation and cancer progression. Indeed, it was …
髓样细胞触发受体-1在炎症性肠病中的研究进展 - 中华炎性肠病杂 …
人膜表面的TREM-1是一种234个氨基酸的I型跨膜蛋白,由一个细胞外免疫球蛋白(Ig)样结构域(184个氨基酸),一个带正电荷的赖氨酸残基的跨膜区和一个短的细胞质尾(5个氨基酸) …
TREM1 activation of myeloid cells promotes antitumor immunity
2023年8月30日 · In this study, we describe PY159, a humanized, afucosylated, agonistic immunoglobulin G1κ (IgG1κ) antibody that specifically binds human TREM1. Because of its …
Targeting TREM1 augments antitumor T cell immunity by …
2023年8月31日 · To investigate the therapeutic potential of TREM1 in cancer, we used mice deficient in Trem1 and developed a novel small molecule TREM1 inhibitor, VJDT. We …
sTREM-1 is a specific biomarker of TREM-1 pathway activation
2021年7月19日 · Here, we aimed to decipher the molecular mechanisms and regulation of TREM-1 expression and sTREM-1 release with the objective of establishing a rationale for the use of …
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