TREM1（Triggering receptor expressed on myeloid cells-1）是一种在中性粒细胞、单核细胞、巨噬细胞表面表达的 髓系细胞 触发受体。 TREM-1以两种形式存在：膜结合受体和可溶性蛋白（sTREM-1）。 膜上的TREM-1有3个不同的结构域：一个Ig样结构，一个跨膜部分和一个与适应分子TYROBP（通常称为 DAP12）相关联的胞质尾部。 这个复合物通过DAP12中带负电的（-）天冬氨酸和TREM-1胞质内尾部带正电的（+）赖氨酸之间独特的静电作用而稳定下来，这对信 …

trem-1选择性地表达于血液中性粒细胞和单核细胞，通过激活这些细胞，引起 白介素-8 （il-8）、 单核细胞趋化蛋白-1 （mcp-1）、 肿瘤坏死因子-α （tnf-α）等炎症前化学增活素的分泌，从而在炎症反应中发挥重要作用。

TREM1（Triggering receptor expressed on myeloid cells-1）是一种在中性粒细胞、单核细胞、巨噬细胞表面表达的髓系细胞表面受体，在多种肿瘤微环境中均表达，协同经典的 模式识别受体 （PRR），例如Toll-like受体（TLR）家族和Nod-like受体（NLR）家族，在宿主防御中放大由微 ...

2023年2月7日 · Triggering receptors expressed on myeloid cells (TREMs) are a family of cell-surface receptors expressed broadly on myeloid cells. The first TREM identified, TREM1, was characterized as an...

Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene.

2024年6月1日 · Over the past decade, there has been growing evidence for the involvement of TREM1 overactivation in tumor stroma inflammation and cancer progression. Indeed, it was shown that TREM1 promotes tumor progression, immunosuppression, and resistance to therapy by activating tumor-infiltrating myeloid cells.

人膜表面的TREM-1是一种234个氨基酸的I型跨膜蛋白，由一个细胞外免疫球蛋白（Ig）样结构域（184个氨基酸），一个带正电荷的赖氨酸残基的跨膜区和一个短的细胞质尾（5个氨基酸）组成，其中带有正电荷的跨膜区可以与DNAX活化蛋白（DNAX -activating protein，DAP12）相互作用 [1]。 TREM-1是其家族中研究最多的受体，在分化的单核细胞和循环血液的中性粒细胞，以及肺泡、肝脏和肠道的巨噬细胞中均可发现 [2, 3, 4, 5]。 除髓样细胞外，TREM-1也在非髓样细胞类 …

2023年8月30日 · In this study, we describe PY159, a humanized, afucosylated, agonistic immunoglobulin G1κ (IgG1κ) antibody that specifically binds human TREM1. Because of its enhanced Fcγ receptor (FcγR) binding, PY159 can cross-link TREM1 to induce signaling through DAP12 and activates proinflammatory signaling in myeloid cells.

2023年8月31日 · To investigate the therapeutic potential of TREM1 in cancer, we used mice deficient in Trem1 and developed a novel small molecule TREM1 inhibitor, VJDT. We demonstrated that genetic or pharmacological TREM1 silencing significantly delayed tumor growth in murine melanoma (B16F10) and fibrosarcoma (MCA205) models.

2021年7月19日 · Here, we aimed to decipher the molecular mechanisms and regulation of TREM-1 expression and sTREM-1 release with the objective of establishing a rationale for the use of sTREM-1 as a marker...