TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival. TREM2 variants cause Nasu-Hakola disease …

2023年11月3日 · The biology of soluble TREM2 (sTREM2), shed from activated microglial cells from its precursor TREM2, is a focus of AD research because TREM2-activating antibodies, …

2023年1月23日 · As seen by SPECT imaging, much more ATV:TREM2 flooded the mouse brain (right) after intravenous injection than anti-TREM2 without the antibody transport vehicle (left). …

2018年2月7日 · TREM2 is associated with the risk of Alzheimer's disease in Spanish population. Neurobiol Aging. 2013 Jun;34(6):1711.e15-7. Epub 2013 Feb 5 PubMed. Finelli D, Rollinson …

2018年3月13日 · The TREM2 knockout microglia poorly phagocytosed beads in culture, while BAC-TREM2 mice ate voraciously, in agreement with previous studies suggesting that TREM2 …

2020年7月14日 · Availability: TREM2 mice are available through Marco Colonna. Summary. This mouse model, referred to here as TREM2 CV, expresses the common variant of human …

2024年4月26日 · TREM2 expression correlated with the amount of senescent proteins, causing the authors to wonder if TREM2 might help trigger this cell state. Supporting this, when the …

2022年3月17日 · TREM2 is a cell surface receptor of the immunoglobulin superfamily that is expressed exclusively in the myeloid lineage cells, particularly microglia in the central nervous …

2024年5月21日 · As mentioned above, TREM2-sol mice generated very little sTREM2, compared with mice that express wild-type TREM2. Levels of TREM2 protein in the forebrains of TREM2 …

2023年11月3日 · The biology of soluble TREM2 (sTREM2), shed from activated microglial cells from its precursor TREM2, is a focus of AD research because TREM2-activating antibodies, …