2010年5月21日 · We found that the hydrophobicity of residue 26, which is normally imparted by Trp in HNP1, is essential for the functional versatility of this host defense peptide. Materials …

2012年3月16日 · Human myeloid α-defensins called HNPs play multiple roles in innate host defense. The Trp-26 residue of HNP1 was previously shown to contribute importantly to its …

2010年5月21日 · We performed a comprehensive alanine scan of human alpha-defensin HNP1 and tested the ability of the resulting analogs to kill Staphylococcus aureus, inhibit anthrax …

2010年2月3日 · Trp-26 imparts functional versatility to human alpha-defensin HNP1. We performed a comprehensive alanine scan of human alpha-defensin HNP1 and tested the …

We performed a comprehensive alanine scan of human -de-fensin HNP1 and tested the ability of the resulting analogs to kill Staphylococcus aureus, inhibit anthrax lethal factor, and bind …

2010年3月1日 · We performed a comprehensive alanine scan of human α-defensin HNP1 and tested the ability of the resulting analogs to kill Staphylococcus aureus, inhibit anthrax lethal …

The activities lost by W26A-HNP1 were restored progressively by replacing W26 with non-coded, straight-chain aliphatic amino acids of increasing chain length. The hydrophobicity of residue …

2012年3月16日 · Surface plasmon resonance studies revealed that Trp-26 mediated the association of monomers and canonical dimers of HNP1 to immobilized HNP1, LF, and gp120, …

We performed a comprehensive alanine scan of human α-defensin HNP1 and tested the ability of the resulting analogs to kill Staphylococcus aureus, inhibit anthrax lethal factor, and bind …

MedChemExpress References: PMID: 20220136 We performed a comprehensive alanine scan of human alpha-defensin HNP1 and tested the ability of the resulting analogs to kill …