2023年7月5日 · Here, we review the history of TRP channel discovery, summarize the structures and functions of the TRP ion channel family, and highlight the current understanding of the role of TRP channels in...

2011年3月17日 · The TRP family is subdivided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), TRPA (ankyrin) and TRPN (NOMPC-like); the latter is found only in invertebrates and fish.

2001年6月1日 · Transient receptor potential (TRP) channels are tetramers assembled from subunits with six membrane-spanning domains, are permeable to monovalent cations and calcium, and are linked to...

2022年10月17日 · We show that native TRPC channels are macro-molecular complexes with an apparent size of around 1 MDa and uncovered distinct homomer and heteromer formation among the TRPC family members. Moreover, we resolved the interactome(s) of native TRPC channels and identified direct interaction between TRPC1/C4/C5 channels and the metabotropic glutamate ...

TRPC channels are activated when phospholipase C is activated either by a Gq-coupled GPCR pathway mediated by PLCβs or by a receptor tyrosine kinase signaling pathway mediated by the γ family of PLCs.

2018年4月26日 · TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the family of canonical transient receptor potential (TRPC) channels. They are activated by diacylglycerol, a...

2004年12月6日 · TRP superfamily proteins fall into one of the three major families on a phylogenetic basis: the TRPC or canonical TRP family, with seven members (TRPC1 through TRPC7), which are the most closely related to the original Drosophila TRP channel; the TRPV family, with six members (TRPV1–6) named after the first group member, the vanilloid ...

TRPC (canonical) family. Members of the TRPC subfamily (reviewed by [2,8,35,41,101,165,275,287]) fall into the subgroups outlined below. TRPC2 is a pseudogene in humans. It is generally accepted that all TRPC channels are activated downstream of G q/11-coupled receptors, or receptor tyrosine kinases (reviewed by [283,354,398]).

2011年12月3日 · The transient receptor potential (TRP) multigene superfamily encodes integral membrane proteins that function as ion channels. Members of this family are conserved in yeast, invertebrates and vertebrates. The TRP family is subdivided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM ( …

2014年1月1日 · This chapter deals with TRPC channels—transient receptor potential canonical channels—as structural components of ROCE channels, their functional relationship and interaction with SOCE channels formed by ORAI proteins, and the multiple roles in physiology and pathophysiology (health and disease) that TRPC channels have been found to have.