TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family. [5] [6]

Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel protein that is required for Ca2+ homeostasis. Recently, more and more evidences have certificated that TRPC1 is necessary for the cellular functions, such as cell proliferation, differentiation and apoptosis, and involved in diverse physiological processes.

2024年12月25日 · TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1) is a Protein Coding gene. Diseases associated with TRPC1 include Pyloric Stenosis and T Cell And Nk Cell Immunodeficiency. Among its related pathways are Cardiac conduction and Nervous system development.

Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7). TRPCs exhibit the highest protein sequence similarity to the Drosophila melanogaster TRP channels.

Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel protein that is required for Ca2+ homeostasis. Recently, more and more evidences have certificated that TRPC1 is necessary for the cellular functions, such as cell proliferation, differentiation and apoptosis, and involved in diverse physiological processes.

2025年2月6日 · As expected, loss of endothelial TRPC1 amplified blood pressure and decreased acetylcholine-induced intracellular Ca 2+ concentration rise in the aorta. In endothelial-specific TRPC1-deficient mouse arteries, the mRNA profile identified upregulation of c-Fos (Fos proto-oncogene, activator protein-1 transcription factor subunit).

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-operated calcium-permeable nonselective cation channels of the TRP superfamily. The seven mammalian TRPC members, which can be further divided into four subgroups (TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7) based on the …

TrpC通道（英文：Transient receptor potential cation channel，简称TrpC通道）是一类重要的离子通道蛋白，属于Transient Receptor Potential（TRP）超家族。 这种通道能够传输多种阳离子，如钙离子（Ca^2+）、钠离子（Na^+）、镁离子（Mg^2+）和铁离子（Fe^2+）。 TrpC通道在细胞的生理和病理过程中起着重要作用，特别是在感知和调节细胞内外环境变化方面发挥关键作用。 TrpC通道是一类非选择性离子通道，能够介导细胞对多种物质和刺激的应答。 它们参与调控 …

TRPC1 interacts with a diverse group of proteins including ion channel subunits, receptors, and cytosolic proteins to mediate its effect on Ca (2+) signaling. It primarily functions as a cation nonselective channel within pathways controlling Ca (2+) entry in response to cell surface receptor activation.

经典瞬时感受器电位通道1(classical transient receptor potential channel 1,TRPC1)是具有六次跨膜结构的非选择性阳离子通道,能通透钙离子和钠离子。 它是哺乳类动物中第一个被发现的TRP蛋白,隶属于TRPC亚家族。