Transient Receptor Potential Melastatin 8 (TRPM8) is a member of the TRP ion channel family; its major physiological activator is cold, and it is also activated by “cooling agents” such as menthol. TRPM8 is a well established physiological sensor of environmental cold temperatures.

This chapter focuses on TRPM8, describing what was known about cold signaling before the channel was cloned, how TRPM8 was identified as a cold sensor, and what advances have been made in our understanding of the molecular logic for cold sensation since its identification.

2020年9月5日 · The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca 2+ homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the transient receptor potential (TRP) channel subfamilies and exploited so far to reach ...

Transient receptor potential melastatin 8 (TRPM8) channels play a central role in the detection of environmental cold temperatures in the somatosensory system. TRPM8 is found in a subset of unmyelinated (C-type) afferents located in the dorsal root (DRG) and trigeminal ganglion (TG).

2020年9月5日 · Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation …

2023年10月18日 · Melastatin-like transient receptor potential (TRPM) channels are multifunctional cation channels with diverse biophysical and physiological characteristics. Eight family members have been...

2020年7月29日 · Menthol in mints elicits coolness sensation by selectively activating TRPM8 channel. Although structures of TRPM8 were determined in the apo and liganded states, the menthol-bounded state is...

2021年8月7日 · The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated by low temperatures (>10, <28 °C), but also a polymodal ion channel, stimulated by voltage, pressure, cooling compounds (menthol, icilin), and hyperosmolarity.

Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortly thereafter, the protein was identified as a cold- and menthol-activated ion channel in peripheral sensory neurons, where it plays a critical role in cold temperature detection.

TRPM8 is a thermosensor protein primarily activated by cool temperatures and certain cooling compounds like menthol, icilin, and eucalyptol. It is expressed in specific neurons in sensory ganglia and lacks ankyrin repeat domains in the N-terminus. AI generated definition based on: Current Opinion in Pharmacology, 2015