The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene.

The transient receptor potential vanilloid 1 (TRPV1) channel is predicted to have six transmembrane domains and a short, pore-forming hydrophobic stretch between the fifth and sixth transmembrane domains (see Figure 5.1A).

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel.

TRPV1（transient receptor potential vanilloid-1）是配体门控的非选择性阳离子通道，属于瞬时受体电位通道家族，能够被多种物理和化学刺激激活。 TRPV1是药物研发的重要靶点之一，其异常刺激和表达与多种疾病的发病机制有关。 一直以来，TRPV1因其调节剂优异的镇痛效果而备受关注。 2021年诺贝尔生理学奖对温度和触觉感受器研究工作的认可，使TRPV1再一次成为关注的焦点。 TRPV1已有20多年的研究基础，但是其门控机制和药物研发仍然是研究的难点。 本文 …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators. TRPV1 is found in the …

2024年10月1日 · TRPV1 is a key bridge in neuroimmune interactions, allowing for smooth and convenient communication between the two systems. Here, we discuss the coordinated cross-talking between the immune and nervous systems and the functional role and the functioning manner of the TRPV1 involved.

2025年1月26日 · TRPV1 receptors, which are distributed at all levels of the nervous system, regulate nerve reflexes and sensory transduction in response to sleep disturbances caused by various stimuli such as apnea, and chronic pain.

2006年10月1日 · The capsaicin receptor TRPV1 is an emerging target for the treatment of pain with a unique expression profile in peripheral nociceptors and the ability to show polymodal activation, TRPV1 is an important integrator of responses to inflammatory mediators.

The transient receptor potential vanilloid 1 (TRPV1) channel is predicted to have six transmembrane domains and a short, pore-forming hydrophobic stretch between the fifth and sixth transmembrane domains (see Figure 5.1A).

First studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 is now recognized to have a broader distribution and function within the central nervous system (CNS).