TRPV4 as a Therapeutic Target in Neurological Disease. The therapeutic potential of TRPV4 modulation is a rapidly evolving field due to the key role of TRPV4 in various diseases. We explore the molecular mechanisms through which TRPV4 contributes to disease pathogenesis in conditions such as inflammation, neuropathic diseases (e.g., Alzheimer ...

Transient Receptor Potential (TRP) channels are a family of ion channels whose members are distributed among all kinds of animals, from invertebrates to vertebrates. The importance of these molecules is exemplified by the variety of physiological roles they play.

The TRPV4 gene provides instructions for making a protein that acts as a calcium channel. This channel, which transports positively charged atoms of calcium (calcium ions) across cell membranes, is found in many types of cells and tissues.

TRPV4, the fourth member of the vanilloid subfamily of TRP channels, is a calcium-permeable cation channel that is detectable in both sensory and nonsensory cells. It has been shown to be widely expressed, including in kidneys, lungs, hearts, brains, endothelial cells, and dorsal root and trigeminal sensory ganglia.

2014年5月15日 · The autosomal dominant TRPV4 disorders (previously considered to be clinically distinct phenotypes before their molecular basis was discovered) are now grouped into neuromuscular disorders and skeletal dysplasias; however, the …

The expression of TRPV4 in tissues that show flow- or shear stress-dependent Ca 2+ entry like flow-sensitive nephron segments and the vascular endothelium make TRPV4 a candidate for a channel sensitive to these stimuli.

2024年12月25日 · TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a Protein Coding gene. Diseases associated with TRPV4 include Metatropic Dysplasia and Hereditary Motor And Sensory Neuropathy, Type Iic. Among its related pathways are Ion channel transport and CREB Pathway.

2019年6月24日 · We herein reviewed the research focus on the relationship between TRPV4 and cancer, also explored the mechanism of TRPV4-mediated oncogenesis and the strategy that target TRPV4 for tumor...

The Trpv4 channel expressed in vitro in CHO cells was opened by low pH, citrate, and inflation but not by heat or capsaicin. These data identified the TRPV4 channel as essential for the normal detection of pressure and as a receptor of the high-threshold mechanosensory complex.

TRPV4 is involved in maintaining homeostasis, serves as an osmosensor and thermosensor, can be activated directly by endogenous or exogenous chemical stimuli, and can be activated or sensitized indirectly via intracellular signaling pathways.