Role of the Rap1 GTPase in astrocyte growth regulation
The TSC2 gene product, tuberin, encodes a GTPase-activating protein (GAP) domain, which regulates the activity of Rap1 in vitro. To determine whether dysregulated Rap1, resulting from …
Expression of the TSC2 product tuberin and its target Rap1 in …
TSC2 encodes the protein tuberin, which is a widely expressed 180-kd polypeptide that exhibits specific GTPase activating activity toward Rap1 in vitro and co-localizes with Rap1 in cultured …
Structural insights into TSC complex assembly and GAP activity …
2021年1月12日 · We propose a model of Rheb-bound TSC complex based on structural superimposition with GTP-bound Rheb 18 and Rap1–Rap1GAP 19 structures. Our structure …
TSC2: filling the GAP in the mTOR signaling pathway
2004年1月1日 · TSC2 contains a region (amino acids 1517–1674) of limited homology to the catalytic domain of the Rap1-GAP. This GAP domain is highly conserved in TSC2 homologs …
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
In the present review we focus on the molecular details of TSC1–TSC2 complex regulation and function as it relates to the control of Rheb and mTORCl. Keywords: cell growth control, …
Biochemical and Functional Characterizations of Small GTPase …
Tuberous sclerosis complex (TSC) is a genetic disease caused by a mutation in either the tsc1 or tsc2 tumor suppressor gene. Recent studies have demonstrated that TSC2 displays GAP …
Co-localization of the TSC2 product tuberin with its target Rap1 in …
1996年9月5日 · The co-localization of tuberin and Rap1 in vivo strengthens the likelihood that the in vitro catalytic activity of tuberin toward Rap1 plays a physiologically relevant role in the …
Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and
2003年8月29日 · In this study, in an effort to understand its mechanism of action, we investigated whether TSC2 could regulate Rap1 or related GTPases in vivo. Our results suggest that TSC2 …
Expression of the TSC2 product tuberin and its target Rap1 in …
TSC2 encodes the protein tuberin, which is a widely expressed 180-kd polypeptide that exhibits specific GTPase activating activity toward Rap1 in vitro and co-localizes with Rap1 in cultured …
Rheb GTPase is a direct target of TSC2 GAP activity and regulates …
Here we report that TSC2 is a GTPase-activating protein (GAP) toward Rheb, a Ras family GTPase. Rheb stimulates phosphorylation of S6K and 4EBP1. This function of Rheb is …