A tuberous sclerosis complex signalling node at the peroxisome ...
2013年8月18日 · We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS).
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
2010年2月16日 · Our results identify a cytoplasmic pathway for ROS-induced ATM activation of TSC2 to regulate mTORC1 signaling and autophagy, identifying an integration node for the cellular damage response with key pathways involved in …
TSC on the peroxisome controls mTORC1 - Nature Cell Biology
2013年10月1日 · On page 1186, Zhang and co-workers report that the mTORC1 regulators TSC1, TSC2 and Rheb localize to the peroxisome where they control mTORC1 activity in response to reactive oxygen species...
A TSC signaling node at the peroxisome regulates mTORC1 and …
We report that the tuberous sclerosis complex (TSC) signaling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). TSC1 and TSC2 were bound by PEX19 and PEX5, respectively, and peroxisome-localized TSC functioned as a Rheb GAP to suppress mTORC1 and induce autophagy.
ATM at the crossroads of reactive oxygen species and autophagy
2021年7月22日 · In response to elevated ROS (both exogenous ROS such as H 2 O 2 or doxorubicin and endogenous ROS such as menadione or phenylethylisothiocyanate), cytoplasmic ATM acts as an ROS sensor and activates the tuberous sclerosis 2 (TSC2) tumor suppressor via the Liver kinase B1 (LKB1) / Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK ...
Tuberous sclerosis complex 2 loss-of-function mutation regulates ...
2008年3月28日 · The effect of a mutant TSC2 and, thereby, high Rac1 activation on ROS generation was evaluated by transfecting mutant TSC2 into COS-1 cells. ROS production was measured with DCF-DA. We found a significantly increase in Rac-1 activity (Fig. 2 A) as well as ROS production in cells introducing TSC2 R611Q or TSC2 Y1571H into COS-1 cells (Fig. 4 A ...
Lithium promotes the production of reactive oxygen
2018年3月1日 · In this study, the mechanism that lithium (Li) promotes the production of reactive oxygen species (ROS) via the glycogen synthase kinase-3β (GSK-3β)/tuberous sclerosis complex 2 (TSC2)/target of rapamycin (TOR) signaling was investigated in the gill of …
mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis …
In this paper, authors demonstrated that peroxisomal ROS stimulate autophagy by activating TSC2 and repressing mTORC1 and suggested that peroxisomal TSC signaling node functions as a cellular sensor for ROS to regulate mTORC1 and autophagy.
TSC2 participates TSC1 TSC in energy sensing and growth factor signaling to repress the kinase mTOR in the mTORC1 complex, a key regulator of protein syn-thesis and cell growth (7, 8).
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
2010年3月2日 · We show that in response to elevated ROS, ATM activates the TSC2 tumor suppressor via the LKB1/AMPK metabolic pathway in the cytoplasm to repress mTORC1 and induce autophagy. Importantly, elevated ROS and dysregulation of mTORC1 in ATM-deficient cells is inhibited by rapamycin, which also rescues lymphomagenesis in Atm-deficient mice.