Phospho-Tuberin/TSC2 (Ser939) Antibody detects endogenous levels of tuberin only when phosphorylated at serine 939. This antibody does not cross-react with tuberin phosphorylated …

2014年2月13日 · We demonstrate that insulin stimulates acute dissociation of the TSC complex from the lysosomal surface, where subpopulations of Rheb and mTORC1 reside. The TSC …

2003年11月26日 · TSC2 integrates signals from multiple pathways to regulate translation, cell size, and apoptosis. Activation of TSC2 by AMPK-dependent phosphorylation prepares cells …

2020年12月3日 · Akt phosphorylates TSC2 at a common recognition motif, RxRxxS/T (R, arginine; S, serine; T, threonine; x, any amino acid), that is located at multiple sites, including …

Mutation of two specific phosphorylation sites (S939 and S981) prevents the cytosolic translocation of tuberin from cellular membranes and results in a constitutively active protein …

2007年12月13日 · Akt directly phosphorylates two sites on TSC2 (S939 and T1462), which destabilizes TSC2 and disrupts its interaction with TSC1 2, 3. These Akt phosphorylations are …

2019年9月20日 · DAPK1 interacts with TSC2 via its death domain and mediates TSC2-S939 phosphorylation. Phosphorylation of TSC2 at serine 939 promotes its disassociation with …

This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S939 of human TSC2. …

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. Maintain …

2005年4月22日 · Recently, extracellular signal-regulated kinase (Erk) has been found activated in TSC lesions lacking TSC1 or TSC2 LOH. Here, we show that Erk may play a critical role in …