研究发现，长期注射锂的小鼠脑部GSK-3活性被抑制，神经元细胞发生NFAT3/4的核转位，从而诱导死亡配体（Fas Ligand，FasL）表达水平的上升，激活FasL/Fas凋亡通路，下游凋亡蛋白酶caspase-3表达增加，从而诱导随后的神经元凋亡。 基于当前环孢菌素A（Cyclosporin A）等药物在神经系统应用的局限性，例如，在体外培养的皮层神经元中， 脑源性神经营养因子 BDNF可以刺激NFAT依赖的转录，而使用CsA和FK506可以阻断该过程；传入神经阻滞可以激活前腹侧的 …

By virtue of its structural property, the TSH receptor (TSHR) has a unique ability to engage different G proteins making it highly amenable to selective signaling. In this study, we describe the identification and characterization of a novel small molecule agonist to the TSHR which induces primary engagement with G αq/11.

2025年2月24日 · In this paper, Gαs-cAMP-PKA and Gαq/11-PLC-Ca 2+, two signal transduction pathways that are intimately associated with TSH function, were successfully used to construct double transfected HEK293-TSHR stable lines containing CRE or NFAT response elements (RE) tagged to a modified form of the luciferase reporter, and two RGAs that are highly ...

2013年12月1日 · Overexpression of S100A4 led to a reduced activation of NFAT by TSH. Using S100A4 E33Q, D63N, F72Q and Y75K mutants we found that the effects of S100A4 expression on Ca 2 + signaling are mediated by protein interaction. We present evidence that TSH has the ability to fine-tune Ca 2 + signals through the regulation of CaBP expression. This ...

2023年10月23日 · Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to...

2005年6月1日 · NFAT proteins cooperate with lineage-specific transcription factors to determine pathways of T helper (T H)-cell differentiation into T H 1- or T H 2-cell populations. Programmes of gene...

In this review, we address the possible reasons for these distinct roles, particularly regarding N- and C-terminal transactivation regions (TADs) and the partner proteins that interact with these TADs. We also discuss the genes regulated by NFAT during cell cycle regulation and apoptosis and the role of NFAT during tumorigenesis.

2024年1月1日 · As a transcriptional activator widely expressed in various tissues, nuclear factor of activated T cells (NFAT) is involved in the regulation of the immune system, the development of the heart and brain systems, and classically mediating pathological processes such as …

2020年6月26日 · By virtue of its structural property, the TSH receptor (TSHR) has a unique ability to engage different G proteins making it highly amenable to selective signaling. In this study, we describe the identification and characterization of a novel small molecule agonist to the TSHR which induces primary engagement with G αq/11 .

The NFAT family of transcription factors plays an established role in T cell activation. Rao and colleagues show that NFAT also controls the program of T cell exhaustion by regulating the expression of key inhibitory receptors and signaling molecules that dampen TCR signaling.