Thyroid stimulating immunoglobulins (TSI) is a relatively new method for assessing TSH-receptor antibodies. The aim of this study was to investigate the role of TSI in the management of GO.

2021年12月28日 · TSI 的生物效应类似促甲状腺激素（TSH），与表达 于甲状腺滤泡上皮细胞膜上的 TSH 受体 (TSHR)结合，激活腺苷酸环化酶信号系统，刺激滤 泡上皮细胞增生，甲状腺弥漫性肿大，合成分泌甲状腺激素增加，进而导致各系统兴奋性增 高，代谢亢进。 长久以来，我们只能检测到血清中总的促甲状腺激素受体抗体（TRAb），而 TRAb 又包 含了 3 类抗体：抑制性的促甲状腺激素受体抗体（TBI）——这是这类抗体会导致加减；中 性的促甲状腺激素受体抗体—— …

What is the best TRAb test for diagnosing GD? Should we be using the thyroid-stimulating Ig (TSI), TSH-binding inhibiting (TBI) Ig, or the new bioassays? Are TRAb levels predictive of relapse and/or response to antithyroid drug therapy in GD? Should TRAb be measured in all pregnant women with GD, and when?

immunoglobulins (TSI) bind to the TSH receptor (TSHR) and mimic TSH stimulation of the thyroid gland.1 Because TSI induced thyroid hormone secretion is not controlled by negative feedback, such stimulation leads to GD hyperthyroidism.2 The TSH receptor contains a large extracellular domain that presents epitopes

促甲状腺激素(thyroid stimulating hormone，TSH)受体抗体(TSH receptor antibody，TRAb)在自身免疫性甲状腺病患者体内特异性存在，其中甲状腺刺激性抗体(thyroid stimulating antibody，TSAb)/TSI受体刺激性免疫球蛋白(TSI)被认为是Graves病(Graves′ disease，GD)的致病 …

Thyrotropin receptor (TSHR) antibodies that stimulate the thyroid (TSAb) cause Graves' hyperthyroidism and TSHR antibodies which block thyrotropin action (TBAb) are occasionally responsible for hypothyroidism. Unusual patients switch from TSAb to TBAb (or vice versa) with concomitant thyroid function changes.

2022年8月8日 · Persistent direct activation of the TSHR by TSI overcomes the physiological hypothalamic–pituitary–thyroid negative feedback loop, leading to elevated thyroid hormones despite low levels of...

2024年7月22日 · 促甲状腺素受体（Thyrotropin receptor, TSHR）是一种细胞表面糖蛋白受体，属于A类G蛋白偶联受体（GPCRs）超家族的LGR亚家族，并与Gs蛋白相连接。TSHR主要在甲状腺组织中表达，但其mRNA和蛋白也存在于神经组织、免疫细胞、眼肌、骨骼、脂肪细胞、红细胞、 …

促甲状腺素受体抗体英文缩写为trab或tshr抗体，是甲状腺b淋巴细胞针对tshr产生的一种自身抗体。 TRAb是由于基因突变等原因导致人体内促甲状腺激素受体（TSHR）结构发生改变，TSHR获得免疫原性，引起甲状腺自身免疫性反应所产生的。

2016年12月5日 · The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves’ disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or cleavage domain …