2024年5月9日 · TB blood tests (interferon-gamma release assay or IGRA) are methods of determining whether a person is infected with TB bacteria. TB blood tests measure the immune response to TB proteins in whole blood. Two TB blood tests are commercially available and approved by the U.S. Food and Drug Administration.

There are currently two tests for diagnosing latent tuberculosis infection (LTBI); TST and IGRA. However, it is still unclear that which one of these tests performs better in high TB-burden settings. 1511 household contacts of pulmonary TB patients were enrolled to compare the performance of TST and IGRA for LTBI.

When it comes to testing for TB infection, there are two main options: the Interferon-Gamma Release Assay (IGRA), also known as the blood test, and the Tuberculin Skin Test (TST), simply known as the skin test. The IGRA test uses a blood sample to measure the immune response to TB-specific antigens, while the TST involves injecting a small ...

Review question: Among people at high risk of TBI who are not treated with TB preventive therapy, which test (e.g. TST or IGRA), when positive, can best identify individuals most at risk of progression?

2024年4月3日 · This study provides updated information regarding the added benefit of IGRAs over the TST, even when a positive TST result is known, and supports the benefits of TBI treatment to prevent TB disease. Our results are consistent with the UK Prognostic Evaluation of Diagnostic IGRAs Consortium (PREDICT) TB study conducted by Abubakar et al, 17 ...

Both currently available tests – the TST and IGRAs – are indirect and require a competent immune response to identify people infected with TB. A positive test result by either method is not by itself a reliable indicator of the risk of progression to active disease.

Both assays measure gamma interferon production following either whole-blood (QFT-GIT) or mononuclear cell (T-Spot) incubation with antigens derived from M. tuberculosis. These procedures have been given the common name of interferon gamma release assays (IGRAs).

The tuberculin skin test (TST) frequently yields false positive results among BCG-vaccinated persons thereby limiting its diagnostic value particularly in settings with high BCG vaccination rate. We determined the agreement between IGRA and TST ...

Both the tuberculin skin test (TST) and IGRAs are aids in the diagnosis of TB infection and active TB disease. Neither test type can definitively rule TB in or out.

In 2011, WHO issued recommendations on the use of IGRAs for the diagnosis of TB infection. In 2018, WHO updated the recommendations to stipulate that the TST or IGRAs (or both) can be used for TB infection.