Total therapy 2 without thalidomide in comparison with total …
2006年4月1日 · We now report on the clinical outcome of 345 patients treated with TT2 without thalidomide in comparison with 231 patients receiving TT1. For both trials, patients had to …
Eight-year median survival in multiple myeloma after total therapy …
TT2's major advance vis-à-vis TT1 pertained to the subgroup without cytogenetic abnormalities (CA), supporting the role of post-transplant consolidation therapy, whereas the improved …
Results of total therapy 2 (TT 2), a phase III randomized trial, to ...
Background: Given the marked activity of THAL in end-stage MM, TT2 was designed (1) to determine THAL’s activity in the context of intensive induction, tandem autotransplants, …
Improvement in long-term outcomes with successive Total
2012年6月18日 · In TT1 (n =231), a phase II trial, induction therapy included three cycles of VAD (vincristine, doxorubicine, dexamethasone), high-dose cyclophosphamide for collection of …
Eight-year median survival in multiple myeloma after total therapy …
Adjusting for prognostic variables in multivariate and pair-mate analyses, TT2 was superior to TT1 in terms of CR duration, event-free and overall survival. These results provide a basis for the …
Total Therapy 2 (No Thalidomide Arm, TT2-) Is Superior to Total …
2005年11月16日 · We now report on the outcome of patients treated on the “no thalidomide” arm of TT2 (TT2-) in comparison to TT1, in order to evaluate the effect of dose-intensification …
Second malignancies in total therapy 2 and 3 for newly ... - PubMed
2012年8月23日 · In the present study, we analyzed data from the Total Therapy 2 (TT2) trial, along with the 2 Total Therapy 3 (TT3) trials. TT2 patients were assigned randomly to either a …
CLINICAL TRIALS AND OBSERVATIONS Clinical Trials and …
2006年4月1日 · To evaluate the benefit of TT2's posttandem autotransplant consolidation chemotherapy and dexamethasone maintenance, outcomes were compared on TT2 without …
Total Therapy 2 (TT2) for Multiple Myeloma (MM): Thalidomide (T ...
2005年11月16日 · Background: Autotransplants have become the standard of care for patients with MM. TT2, a prospective randomized phase III trial, evaluated whether adding T, effective …
Chromosome 1q21 abnormalities in multiple myeloma - PMC
The Total Therapy 2 trial (TT2) performed by the UAMS group evaluated the implementation of thalidomide (in TT2) and other novel agents into the initial management strategy for patients …