Consistent with a function in controlling the survival and process formation of neurons, p75 (NTR) is mainly expressed during early neuronal development. In the adult, p75 (NTR) is re-expressed in various pathological conditions, including epilepsy, axotomy and neurodegeneration.

2021年8月31日 · 事实上， p75NTR 结合神经营养素的小分子抑制剂已经在阿尔茨海默病 (AD) 和神经退行性变的模型中显示出效果。 在这里， 作者概述了在体内理解p75NTR多效性功能的最新进展，并提出了对p75NTR及其作为药理靶点的挑战和机遇的综合看法。 图片来源： https://doi.org/10.1016/j.tips.2021.06.006. P75NTR 在多种生物学过程中发挥着重要作用，包括调节细胞死亡和存活、瘢痕形成、能量消耗和缺氧反应，并通过这些过程促进组织修复、新陈代 …

Although p75 neurotrophin receptor (p75 NTR) was the founding member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF), it is an atypical TNFRSF protein. p75 NTR like TNF-R1 and Fas-R contain an extracellular domain with four cysteine-rich domains (CRD) and a death domain (DD) in the intracellular region.

2011年5月11日 · In neurons, p75NTR receptor has a dual function: promoting survival together with TrkA in response to NGF, and inducing apoptotic signaling through p75NTR. We postulated that p75NTR may also affect the survival pathways in the choroid plexus and also undergoes regulated proteolysis with metalloproteases.

2002年11月1日 · P75 NTR is one of roughly 25 members of the TNF receptor superfamily (TNFRSF) 9 and binds all neurotrophins with similar nanomolar affinities 10 . We review here a series of findings that shed...

The emerging role of p75 NTR as a driver of neuropathogenesis: The relationship between neurotrophins and neurodegenerative diseases is best developed for AD, where the loss of cholinergic input from the basal forebrain to the cortex and hippocampus is closely linked to changes in nerve growth factor (NGF) signaling. A major turning point in ...

2024年5月17日 · Over the past two decades, multiple lines of evidence have converged on the p75 neurotrophin receptor (p75 NTR) as a promising deep biology target for modifying neuronal dysfunction and...

2023年8月23日 · The findings described that pharmacological inhibition and genetic knocking down of p75 NTR reduce infarction size, edema, and hemorrhagic transformation following ischemic stroke. Additionally, p75 NTR modulation significantly decreased several anti-apoptosis markers and improved sensory motor function compared to the WT mice following ...

2020年9月11日 · Neurotrophins bind to two distinct types of receptors including p75 neurotrophin receptor (p75NTR) with a lower affinity, as well as to the tropomyosin receptor kinases (Trk) receptors, which...

Recently, the p75 neurotrophin receptor (p75 NTR) has emerged as a potential target for pharmacological control of neurotrophin activity, supported in part by studies demonstrating 1) regulation of neural plasticity in the mature nervous system, 2) promotion of adult neurogenesis and 3) increased expression in neurons, macrophages, microglia ...