tetrodotoxin（TTX）作为电压门控型钠离子通道阻断剂，施加光刺激，此时没有动作电位。 若附加4-AP来阻断 钾离子通道 ，以减小正离子外流的影响，就观测到了动作电位。

2017年11月10日 · 4-AP is used to block K + channel-mediated shunting of the light-evoked response. This increases the membrane space constant and raises the odds that the light …

The TTX/4AP conditions were originally developed for use with laser-scanning photostimulation (subcellular ChR2-assisted circuit mapping, or “sCRACM”) (Petreanu et al. 2009), but can be …

Our results show that co-activation of the two projections induces long-term potentiation (LTP) at vH-to-NAc synapses without affecting BLA-to-NAc synapses, revealing a heterosynaptic …

2020年7月25日 · 这些eEPSC可被钠离子通道阻滞剂（TTX)阻断，同时钾通道阻滞剂（4-AP）可以逆转这种阻断效应（被认为与促进钙内流从而易化突触前囊泡的释放有关）（图1d）。 这 …

2020年11月10日 · Together, TTX and 4AP are often referred to as "network effect block". In other words, you can administer TTX to block any potential "relays" there may be between your two …

如图所示，作者用tetrodotoxin（TTX）作电压门控型钠离子通道阻断剂，施加光刺激，此时没有动作电位。 若附加4-AP来阻断钾离子通道，以减小正离子外流的影响，就观测到了动作电位。

2020年6月1日 · Optogenetically evoked PSC (in TTX/4AP, blue trace) were nearly completely eliminated by 40 μM PTX (+PTX, red trace). Scale bars, 100 pA and 100 ms.

2024年5月8日 · 应用钠通道阻滞剂TTX可以阻断光遗传学刺激诱导的动作电位的产生和传播，从而阻断单突触（2和3，红色电位线）和多突触连接神经元（5和6，红色电位线）动作电位驱动 …

2015年3月4日 · IPSCs could be rescued in the continued presence of TTX by enhancing ChR2-mediated depolarization of terminals with application of the voltage-gated K + channel blocker …