Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets during hemostasis and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation.

2022年9月12日 · Named after its role in thrombosis, TxA2 has prothrombotic properties, as it stimulates the activation of platelets and platelet aggregation. TxA2 is also a known vasoconstrictor and gets activated during times of tissue injury and inflammation.

Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2. The distinguishing feature of thromboxanes is a 6-membered ether -containing ring. Thromboxane is named for its role in blood clot formation (thrombosis).

2022年9月12日 · Named after its role in thrombosis, TxA2 has prothrombotic properties, as it stimulates the activation of platelets and platelet aggregation. TxA2 is also a known vasoconstrictor and gets activated during times of tissue injury and inflammation.

2025年3月5日 · TXA2 acts on T cells to trigger an immunosuppressive pathway that is dependent on the guanine exchange factor ARHGEF1, suppressing T cell receptor-driven kinase signalling, proliferation and ...

Thromboxane A2 (TxA2) is formed in the platelet by the action of thromboxane synthase. It possesses potent vasoconstrictor activity, facilitates cholesterol uptake, induces proliferation of vascular smooth muscle cells, and stimulates platelet aggregation. TxA2 binds to a G-protein–coupled receptor on platelet plasma membranes.

Thromboxane A2 (TXA2), the primary product of COX-1-dependent metabolism of arachidonic acid, mediates its biological actions through the TXA2 receptor, termed the TP. Irreversible inhibition of platelet COX-1-derived TXA2 with low-dose aspirin ...

TxA2 mediates its effect through the thromboxane prostanoid (TP) receptor that is expressed not only in platelets, but also in endothelial cells, macrophages, and monocytes, and thus contributes to the development of atherosclerotic lesions.

2013年12月19日 · TxA2 mediates its effect through the thromboxane prostanoid (TP) receptor that is expressed not only in platelets, but also in endothelial cells, macrophages, and monocytes, and thus contributes to the development of atherosclerotic lesions.

2008年4月1日 · Thromboxane A 2 (TXA 2), an unstable arachidonic acid metabolite, elicits diverse physiological/pathophysiological actions, including platelet aggregation and smooth muscle contraction. TXA 2 has been shown to be involved in allergies, modulation of acquired immunity, atherogenesis, neovascularization, and metastasis of cancer cells.