Moreover, thromboxane B 2 (TXB 2) is an inactive product of TXA 2, which was found in the interstitial space of skeletal muscle. No further studies have been done to assess the role of TXB 2 in DMD. Thromboxane A 2 is the predominant product of the arachidonic acid metabolism of platelets and is a potent platelet-aggregating agent [95].

Thromboxane B2 is an eicosanoid and biologically inactive metabolite of thromboxane A2. Thromboxane B2 is released during anaphylaxis. As thromboxane A2 has a short half-life, the levels of thromboxane B2 can be used to indirectly measure the …

Dec 1, 1994 · We investigated the plasma concentration of thromboxane B2 (TXB2), a stable metabolite of thromboxane A2 (TXA2), to assess platelet activation in 78 patients who had pulmonary hypertension associated with congenital heart disease (PH group) and 16 patients with almost normal hemodynamics (control group).

Thromboxane B2 (TxB2) is the stable, inactive product of prostaglandin metabolism of thromboxane A2, which is renally cleared and, therefore, can be measured in the urine. Studies have shown that thromboxane B2 is a sensitive indicator of platelet activation.

Serum thromboxane B2 (TxB2) is a specific marker of platelet inhibition by aspirin. Yet, TxB2 levels differ by up to 10-fold between some aspirin-treated patient cohorts.

TXB2 has a number of features that differentiate it from conventional IgG-based TfR1 antibodies. Namely, TXB2 exhibits species cross-reactivity and brain tissue selectivity, and penetrates the brain at low doses without depleting reticulocytes from …

The elevated blood level of TxB2 (hyperaggregability of platelets) is significantly related to the level of lipid peroxidation products (oxidative stress) in type 1 diabetic patients. Supplementation of modest doses of vitamin E (100 IU/day) significantly lowers blood TxB2 and …

Low-dose (81-100 mg) aspirin once daily, which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.

In human plasma, 11-dehydrothromboxane (TX) B2 is a major long lived metabolite (t1/2 45 min) formed from infused TXB2, the hydration product of biologically active TXA2.

血栓素(thromboxane，TXB2)是前列腺素中的一种，由血小板产生，具有血小板凝聚及血管收缩作用，与前列腺素作用相反，两者动态平衡以维持血管收缩功能及血小板聚集作用。TXA2生物半衰期仅30s，迅速转化为无活性的血栓素B2(TXB2)。