Tanezumab, a recombinant humanized monoclonal antibody (IgG), was developed to target NGF, binding both circulating and local tissue NGF preventing interaction with the tropomyosin …

2020年4月1日 · The pharmacology of Nerve Growth Factor (NGF) and the discovery and development of tanezumab, a monoclonal anti-NGF antibody for the treatment of pain illustrate …

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory …

The role of NGF in pain transduction, antibodies that block NGF signaling, outcomes of previous proof-of-concept studies on anti-NGF antibodies, and potential benefit of personalized …

神经生长因子（Nerve Growth Factor，NGF）是神经营养因子家族中的生物活性因子之一，由α、β、γ三个亚基组成。 NGF是具有神经营养和促突起生长双重生物学功能的一种神经细胞生长 …

Nerve Growth Factor-β (Beta-NGF; NGF) is a basic protein of 118 amino acids which acts are a trophic factor for sensory and sympathetic neurons of the peripheral nervous system, and on …

2021年9月8日 · Advancements in clinical research on the role of nerve growth factors (NGFs) in pain conditions has led to the development of anti-NGF monoclonal antibodies (mAbs) that …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation, and survival of sympathetic and sensory afferent neurons during development. A substantial body …

Nerve growth factor (NGF) and its precursor (proNGF) are primarily considered as regulators of neuronal function that induce their responses via the tyrosine kinase receptor TrkA and the …

We now provide the "Disease & Variants" viewer in its own tab. The viewer provides 304 variants from UniProt as well as other sources including ClinVar and dbSNP. Go to variant viewer. …