2024年12月25日 · TACSTD2 (Tumor Associated Calcium Signal Transducer 2) is a Protein Coding gene. Diseases associated with TACSTD2 include Corneal Dystrophy, Gelatinous Drop-Like and Corneal Dystrophy. Among its related pathways are Adhesion and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor activity.

It encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

TROP2 属于 TACSTD家族，是由TACSTD2基因编码表达的细胞表面糖蛋白，又名肿瘤相关钙离子信号转导子2（TACSTD2）、表皮糖蛋白1（EGP-1）、胃肠肿瘤相关抗原（GA733-1）、表面标志物1（M1S1） [1]。 TROP-2在多种恶性肿瘤中过表达，是一种与恶性肿瘤发生、侵袭和转移有关的癌基因。 1. TROP2的发现. TROP2最先是被单克隆抗体GA733-1所鉴别而分离到的一种膜抗原，因此被称为GA733-1 [2]。 2. TROP2的结构特征. TROP2基因位于第1号染色体的短臂 …

DAC-002是一款注射用重组人源化抗TROP-2单抗-Tub196偶联剂，拟用于治疗TROP-2阳性三阴性乳腺癌、小细胞肺癌、胰腺癌等实体肿瘤，目前也正在进行临床研究，期待早日为患者带来新的治疗选择。 该药最早由多禧生物开发，2019年君实以3000万元首付款+2.7亿元的里程碑付款获得了该药在日本、韩国之外的亚洲其他国家的开发权益。 [1] Lenart S , Lenart P , Smarda J , et al. Trop2: Jack of All Trades, Master of None [J]. Cancers, 2020. [2] Guerra E, Trerotola M, Aloisi …

2022年6月10日 · In this article, we show that TACSTD2 /Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that...

Two novel mutations of TACSTD2 are found in three Japanese gelatinous drop-like corneal dystrophy families with their aberrant subcellular localization. Trop-2 was highly expressed in uterine serous carcinoma at mRNA and protein levels

2025年1月4日 · Title: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells. Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.

This gene has 1 transcript (splice variant), 194 orthologues, 1 paralogue and is associated with 3 phenotypes. 这种无内含子的基因编码一种癌相关抗原。 该抗原是一种转导钙信号的细胞表面受体。 该基因的突变与凝胶状滴状角膜营养不良有关。 [RefSeq 提供，2009 年 12 月] This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals.

2024年12月12日 · Tumor-associated calcium signal transducer 2 (Tacstd2) stood out as an epithelial-expressed gene with elevated levels early in cystic transformation that further increased with disease progression. Human tissue biopsies and organoids show that TACSTD2 protein is low in normal kidney cells but is elevated in cyst lining cells, making it an ...

tacstd2是一种35kd的跨膜糖蛋白，由tacstd2基因编码而成 ，在调节肿瘤细胞增殖和迁移方面发挥着重要作用 。 相关研究表明，TACSTD2在非小细胞肺癌的组织和细胞株中呈现过度表达，并能促进肺癌细胞的增殖和侵袭 [9] 。