2024年12月27日 · TAP1（Transporter 1, ATP binding cassette subfamily B member）是ATP结合盒（ABC）转运蛋白家族的一员，主要负责将抗原肽从细胞质转运到内质网（ER）腔中。这个过程对于抗原呈递至关重要，因为它确保了MHC I类分子能够与适当的抗原肽结合，从而被呈递到细胞表面，供T细胞 ...

It delivers cytosolic peptides into the endoplasmic reticulum (ER), where they bind to nascent MHC class I molecules. [2] The TAP structure is formed of two proteins: TAP-1 and TAP-2, which have one hydrophobic region and one ATP-binding region each. They assemble into a heterodimer, which results in a four-domain transporter.

2024年12月25日 · TAP1 (Transporter 1, ATP Binding Cassette Subfamily B Member) is a Protein Coding gene. Diseases associated with TAP1 include Mhc Class I Deficiency 1 and Mhc Class I Deficiency. Among its related pathways are Antigen processing-Cross presentation and Class I MHC mediated antigen processing and presentation.

2001年3月1日 · The classical MHC class I antigen processing and presentation pathway is divided into four major steps: the generation of antigenic peptides by proteasomal degradation, the ATP-dependent peptide transport from the cytosol in the ER via the TAP heterodimer, the assembly of MHC class I HC, β 2-m and peptides, which is assisted by various ...

The TAP complex is located in the ER as shown by immunoelectron and immunofluorescence microscopy (Kleijmeer et al., 1992; Meyer et al., 1994). Both proteins lack an NH 2-terminal signal sequence for ER targeting. The complex is retarded in the ER by an internal signal sequence.

Transporter associated with antigen processing 1 (TAP1) is a transporter protein that represent tumor antigen in the MHC I or HLA complex. Any defect in the TAP1 gene resulting in inadequate tumor tracking. TAP1 influences multidrug resistance (MDR) in human cancer cell lines and hinders the treatment during chemotherapeutic.

2022年2月1日 · In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded the successful discovery of transporter associated with antigen processing (TAP) protein.

2 天之前 · ER, TAP1, and proteasome (Protea) were stained by primary antibodies and STAR-Red labelled secondary antibodies, while STAR-Orange labelled secondary antibodies were used for STING. Cells were ...

近日，由美国迈阿密大学米勒医学院和荷兰莱顿大学医学中心肿瘤内科等研究者发现， 靶向干扰抗原加工相关转运蛋白基因-TAP可以增强肿瘤免疫源性并诱导强烈的抗肿瘤免疫反应，相关研究成果发表在《Nature Communications》。 TAP于1990年被克隆出来，位于 HLA-DQ 与DP之间。 该基因由TAP1和TAP2两个基因组成，分别编码产生抗原加工相关转运蛋白TAP1和TAP2，两者形成二聚体发挥生物学效应，参与MHC-I类抗原的递呈及内源性多肽的胞内转运。 目前针对TAP基因 …

TAP 是由 TAP1 和 TAP2 组成的异二聚体复合物，它利用 ATP 将胞质肽跨膜转运到 ER 中。 在 ER 中，它与其他成分一起形成肽装载复合物 (PLC)，该复合物指导将高亲和力肽装载到新生的主要组织相容性复合物 I 类 (MHC-I) 分子上，然后将其转运到细胞表面以呈递给 CD8 + T 细胞。 在树突状细胞 (DC) 中交叉呈递过程中，TAP 在将肽转运至吞噬体和内体中也发挥着至关重要的作用。 由于 TAP 在经典 MHC-I 呈递和交叉呈递中发挥着关键作用，其表达和功能常常受到多种 …