New Biomarkers Catch Tau Before It Tangles | ALZFORUM
2025年2月18日 · Tau pathology in humans or animals, without fail, is made up of the hyperphosphorylated protein. In AD tau is hyperphosphorylated sub-stoichiometrically at …
Tau (AT8); Phospho Tau (Ser 202, Thr 205) | ALZFORUM
2024年2月6日 · AT8, which recognizes paired helical filament (PHF) tau, is one of the most widely used anti-tau antibodies. Immunostaining with AT8 can substitute for more difficult silver …
ALS or Alzheimer’s? Blood Phospho-Tau Could Mean Either
2025年3月20日 · While numerous studies suggest p-tau217 and other p-tau forms possess enhanced specificity for CNS amyloid pathology, it remains crucial to consider the potential …
Cell-Based Assay Matches Tau Strains to Neuropathological …
2025年1月30日 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril …
rTg(tauP301L)4510 - ALZFORUM
2014年12月22日 · T2 mice were then crossed with the CaMKIIα-tTA activator line to create bi-transgenic mice (designated rT2/T2 when homozygous for the MAPT P301L transgene). …
Plasma p-Tau217 Flags Alzheimer’s Pathology in Other Disorders
2025年2月23日 · In the February 10 JAMA Neurology, researchers led by Lawren VandeVrede at the University of California, San Francisco, offer a solution. In an autopsy-confirmed cohort, …
Sleep-wake variation in body temperature regulates tau secretion …
2025年2月26日 · From a mechanistic perspective, while hyperphosphorylated tau is a well-established component of neurofibrillary tangles, soluble non-phosphorylated tau—particularly …
Tau (PHF-1) | ALZFORUM
2024年2月5日 · Site-directed mutagenesis of recombinant tau reinforced this finding: Replacement of either serine-396 or serine-404 with an alanine residue, which cannot be …
Tau (12E8) - ALZFORUM
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 Aug 24;293(5534):1491-5. PubMed. Fatouros C, Pir GJ, Biernat J, Koushika …
Tau P301L | ALZFORUM
2025年1月31日 · However, at young ages (eight to ten weeks), Tau P301L mice actually outperform wild-type littermates in object recognition memory (Boekhoorn et al., 2006). The …