The tau proteins (abbreviated from t ubulin a ssociated u nit [5]) form a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau). [6][7] They have roles primarily in maintaining the stability of microtubules in axons and are abundant in the neurons of the central nerv...

2015年12月3日 · Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein,...

Expression levels of various tau isoforms reflect neuronal maturation state and axonal growth capability. Lower levels of tau expression have been reported in immature regions of the human brain, such as the ganglionic eminence and the rhombic lip, while tau expression pattern and splicing are slightly different in more mature brain regions [ 10 ].

2024年7月16日 · Tau was discovered in 1975 and was one of the first microtubule-associated proteins (MAPs) to be characterized 1. It is expressed primarily in neurons, where it facilitates the assembly of...

2025年3月25日 · Tau pathology is present in the brain of nearly all elderly individuals. 1, 2 Many show Alzheimer’s disease (AD) pathology, defined by tau aggregates in neurons and extracellular amyloid plaques. However, some older individuals show tau aggregates in neurons without plaques, called primary age-related tauopathy (PART). 3, 4 The tau pathology in PART and AD is composed of similar ...

6 天之前 · To investigate if phosphorylated tau accumulation correlates with GRAMD1B expression, free cholesterol, and lipid droplet accumulation, correlation plots were generated by multiplex IF staining of ...

2025年3月24日 · Tau is an intracellular protein that plays a crucial role in stabilizing microtubules. However, it can aggregate into various forms under pathological conditions and be secreted into the brain parenchyma. While the consequences of tau aggregation within neurons have been extensively studied, the effects of extracellular paired helical filaments of tau (ePHF-tau) on neurons and astrocytes are ...

2025年3月23日 · These results suggest that elevating TREM2-WT expression has a modest impact on tau pathology in our model system. Fig. 2. The impact of TREM2 expression on tau pathology (A-C) Representative images of piriform cortical region (A) and quantification (B and C) of p-tau by immunofluorescence staining with AT8 antibody. Scale bar, 500 μm.

All mutations significantly increase 4R tau expression in iPSC neurons and astrocytes. Functional analyses of S305 mutant neurons reveal shared disruption in synaptic signaling and maturity but divergent effects on mitochondrial bioenergetics.

2025年3月13日 · Tau protein, encoded by the microtubule-associated protein tau gene (MAPT) located on chromosome 17, plays a role in regulating organization and dynamics of microtubules [1, 2].Abnormal accumulation of insoluble tau aggregates in neurons and glia is a major neuropathologic feature of a group of neurodegenerative disorders with distinct clinical [3, 4], biochemical [] and neuropathologic ...