Tau protein liquid-liquid phase separation can initiate tau
2018年4月3日 · Here, we propose that soluble tau species can undergo liquid-liquid phase separation (LLPS) under cellular conditions and that phase-separated tau droplets can serve …
Liquid-liquid phase separation induces pathogenic tau ... - Nature
2020年6月4日 · The authors show that disease-related P301L mutant and phosphomimic (S199E/S202E/T205E) tau enhance LLPS in vitro at physiological levels, and using specific …
Liquid − liquid phase separation of tau: Driving forces, regulation ...
2023年7月1日 · Recent findings demonstrate that the microtubule-associated protein tau forms liquid condensates through liquid–liquid phase separation (LLPS) in in vitro experiments using …
Phosphorylation regulates tau’s phase separation behavior and ...
2024年3月1日 · Using in vitro biophysical experiments, here we demonstrate that tau can undergo liquid-liquid phase separation (LLPS) with DNA, mononucleosomes, and reconstituted …
Liquid–liquid phase separation of tau: From molecular biophysics …
Biomolecular condensation via liquid–liquid phase separation (LLPS) of intrinsically disordered proteins/regions (IDPs/IDRs), with and without nucleic acids, has drawn widespread interest …
Tau protein liquid–liquid phase separation can initiate tau …
2018年2月22日 · Here, we propose that soluble tau species can undergo liquid–liquid phase separation (LLPS) under cellular conditions and that phase‐separated tau droplets can serve …
Liquid-liquid phase separation of protein tau: An emerging …
2023年3月1日 · A small natural antioxidant molecule of flavonoid compound, myricetin, has been shown recently to modulate tau LLPS (Dai et al., 2021). This molecule reduces the full-length …
Liquid–liquid phase separation of tau protein: The crucial role of ...
Recent studies have indicated that tau, a protein involved in Alzheimer's disease and other neurodegenerative disorders, has a propensity to undergo liquid–liquid phase separation …
Liquid–Liquid Phase Separation of Tau Protein Is Encoded at the ...
2021年3月9日 · Liquid–liquid phase separation (LLPS) is involved in both physiological and pathological processes. The intrinsically disordered protein Tau and its K18 construct can …
Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase
2021年9月8日 · The microtubule-associated protein tau can undergo liquid-liquid phase separation (LLPS) to form membraneless condensates in neurons, yet the underlying …
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