2016年1月11日 · Genetic manipulation of lamin function significantly modifies neurodegeneration in vivo, demonstrating that lamin pathology plays a causal role in tau-mediated neurotoxicity. We show that lamin dysfunction is conserved in human tauopathy, as super-resolution microscopy reveals a significantly disrupted nuclear lamina in postmortem tissue from ...

2021年4月1日 · Lamin A, which is not typically expressed in neurons, appears at the transformation from senile to AD neurons and contributes to halting the consequences of cell cycle reentry and nuclear Tau exit, allowing the survival of the neuron.

2023年5月10日 · In this review, we have focused on nuclear tau, its preferential localization in regions like the nucleolus or pericentromeric chromatin, and on its interaction with nuclear components like proteins and, mainly, nucleic acids. Finally, we have commented about the role, related to cell aging, of tau in the activation of transposons expression.

In this study, Frost et al. identify the lamin nucleoskeleton and improper cytoskeletal/nucleoskeletal coupling as novel mediators of neurotoxicity in tauopathies, including human Alzheimer’s disease. Their work suggests that …

2021年4月1日 · In this review, we analyze the progressive changes that hippocampal neurons undergo throughout aging and the irreversible nuclear transformation that originates the cytoskeletal pathology in AD. The discussion is centered on …

2016年1月11日 · We show that lamin dysfunction is conserved in human tauopathy, as super-resolution microscopy reveals a significantly disrupted nuclear lamina in postmortem tissue from human Alzheimer’s disease brain.

2016年1月1日 · We show that lamin dysfunction is conserved in human tauopathy, as super-resolution microscopy reveals a significantly disrupted nuclear lamina in postmortem tissue from human Alzheimer’s disease brain.

Tau-DNA interactions suggest a chaperone-like role for Tau in DNA organization and repair, highlighting its involvement in maintaining genomic integrity. This review explores the intricate relationships between Tau, NPC components, and nuclear lamin in the context of AD, providing insights into the mechanisms underlying Tau-induced ...

2016年5月11日 · Tauopathies are age-related progressive neurodegenerative disorders, including Alzheimer's disease, which are pathologically characterized by aggregates of tau protein in the brain. 36 Dominant mutations in the tau gene demonstrate that tau dysfunction is sufficient to cause neurodegeneration in humans. 37 We have previously identified ...

2022年2月1日 · oTau directly binds to lamin proteins and the lamin B Receptor. These proteins also exhibit loss of solubility upon oligomerization, and show loss of nuclear membrane localization. These results suggest that oTau directly acts on proteins in the nuclear membrane to elicit disruption of the nucleocytoplasmic interface.