The tau proteins (abbreviated from tubulin associated unit [5]) form a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau).

Tau蛋白是20世纪70年代中期通过研究微管形成所需的因素而发现的一种低分子量微管相关蛋白（microtubule associated protein，MAP），主要分布在中枢神经系统，多数存在于神经元的轴突中，少数存在于少突胶质细胞中…

2004年12月23日 · Several types of microtubule-associated protein (MAP) have evolved in eukaryotes, including microtubule motors, microtubule plus-end-binding proteins, centrosome-associated proteins, enzymatically active MAPs, and structural MAPs. We focus here on the MAP2/Tau family of structural MAPs, which along with the MAP1A/1B family form one of the ...

2023年5月31日 · Three microtubule-associated proteins (MAPs), MAP2, MAP4, and tau 4, 5, 6, 7, 8, which are the most well-studied mammalian-derived MAPs with similar primary structures, promote microtubule...

2022年1月20日 · We established interactions of Tau with presynaptic vesicle proteins during activity-dependent Tau secretion and mapped the Tau-binding sites to the cytosolic domains of integral synaptic vesicle proteins.

Tau 蛋白，全称 微管 相关蛋白 Tau（MAPT），是一种主要“栖息”于神经元轴突内的特殊蛋白，其与微管的互动模式独具特色，并非紧密、持续相连，而是短暂且间歇的“快速接触”，宛如微观世界里的一场场“快闪互动”。

2016年3月31日 · The microtubule associated protein Tau (MAPT) promotes assembly and interaction of microtubules with the cytoskeleton, impinging on axonal transport and synaptic plasticity. Its neuronal expression and intrinsic disorder implicate it in some 30 tauopathies such as Alzheimer’s disease and frontotemporal dementia.

Tau is a microtubule-associated protein (MAP; Weingarten et al., 1975; Witman et al., 1976) that is abundant in the axons of neurons where it stabilizes microtubule (MT) bundles (Binder et al., 1985; Black et al., 1996). Together with other destabilizing MAPs, such as stathmin, Tau plays a central role in MT dynamics by regulating assembly ...

In cell biology, microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs are integral to the stability of the cell and its internal structures and the transport of components within the cell. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability.

2004年6月1日 · Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. All three vertebrate members of the family have alternative splice forms; all isoforms share a conserved carboxy-terminal domain containing microtubule-bin …