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Thyroid-stimulating antibody (TSAb) and TSH-binding inhibitor immunoglobulin (TBII) have been measured as TRAb to diagnose Graves' disease and to follow Graves' patients. We intended to evaluate the clinical value of TRAb (TSAb and TBII) assay in establishing the diagnosis of Graves' disease and in predicting its clinical course.

TRAb，即TSH受体抗体（TSH：促甲状腺激素）， 广义上可分为TSH受体刺激性抗体（TSAb）、TSH刺激阻断性抗体（TSBAb）和TSH受体结合抑制免疫球蛋白（TBII），在甲亢存在的情况下，则将TRAb定义为TBII。 它们与甲状腺细胞上的TSH受体结合，引起甲状腺增生及甲状腺激素分泌过多或过少，被认为是引起自身免疫性甲状腺疾病的重要因素之一。 TgAb，即甲状腺球蛋白抗体，是最早发现的甲状腺自身抗体， 其主要抗原是甲状腺滤泡胶质中的甲状腺球蛋白，具有 …

Oct 2, 2024 · The thyrotropin receptor antibody (TRAb) test is a blood test that helps healthcare providers diagnose the autoimmune thyroid condition called Graves' Disease. The antibodies it tests for are present in between 90% and 100% of the people who have this disease. Other names for the TRAb test include:

In the present study, thyrotrophin binding inhibitor immunoglobulin (TBII) activites were measured by radioreceptor assay, according to the method of Shewring and Smith 1), in 30 patients with Graves’ disease, 13 patients with Hashimoto’s thyroiditis, 20 patients with lymphocytic thyroiditis with spontaneously resolving hyperthyroidism (LT ...

采用细胞培养生物学方法和放射受体分析法检测甲状腺疾病患者血清甲状腺刺激抗体（TSAb）和促甲状腺激素结合抑制免疫球蛋白（TBII）。 发现Graves病未治组TSAb和TBII活性与阳性率明显高于Graves病缓解组和桥本甲状腺炎（HT）组，后两组TSAb和TBII活性与阳性率高于甲状腺腺瘤组和正常对照组。 Graves病未治组、缓解组和HT组其TSAb和TBII的检出率分别为91.7％和79.2％、48.0％和44.0％及23.1％和61.5％。 甲状腺腺瘤组和对照组TSAb和TBII均为阴性， …

The occurrence of thyrotropin binding inhibiting immunoglobulins (TBII) was studied in 144 patients with different types and stages of Graves' disease (GD) including 2 patients with primary hypothyroidism which changed into hyperthyroid GD.

Sep 9, 2021 · We compared the diagnostic accuracy of the thyroid-stimulating immunoglobulin (TSI) bioassay and thyrotropin-binding inhibitory immunoglobulin (TBII) assay in differentiating GD from other causes of thyrotoxicosis.

促甲状腺激素受体抗体 (TRAb)又称膜受体抗体，是直接作用于甲状腺细胞膜上的TSH受体的抗体，属免疫球蛋白IgG，根据其作用可分为以下3类：①甲状腺刺激性抗体 (TSAb)，又称甲状腺刺激免疫球蛋白 (TSI)，与甲状腺滤泡膜上的TSH受体结合，刺激甲状腺肿大，增强其功能活性，是导致Graves病的主要病因。 ②甲状腺功能抑制性抗体 (TFIAb)：又称甲状腺功能抑制性免疫球蛋白 (TFII)，与TSH受体结合后，可抑制甲状腺功能，引起甲低。 ③甲状腺生长刺激免疫球蛋白 …