tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula (Me 3 C)Me 2 SiCl (Me = CH 3). It is commonly abbreviated as TBSCl or TBDMSCl. It is a chlorosilane containing two methyl groups and a tert -butyl group. As such it is more bulky that trimethylsilyl chloride.

Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

tert -Butyldimethylsilyl chloride (TBDMSCl) is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. [1] [2] It is also used in the preparation of isoxazoline N -oxides from α-bromonitroalkanes and olefins. [3] .

2025年2月24日 · tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes.

test-Butyldimethylsilyl chloride, commonly abbreviated as TBSCl or TBDMSCl, is an organosilicon compound widely used in organic synthesis for the protection of alcohols and amines. Known for its effectiveness in forming silyl ethers, TBSCl is essential in various chemical processes.

tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula (Me 3 C)Me 2 SiCl (Me = CH 3). It is commonly abbreviated as TBSCl or TBDMSCl. It is a chlorosilane containing two methyl groups and a tert -butyl group. As such it is more bulky that trimethylsilyl chloride.

Causes severe skin burns and eye damage. Flammable solid. Toxic to aquatic life with long lasting effects. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Spot an opportunity for improvement?

1-フェニルエタン-1,2-ジオール (276 mg, 2.0 mmol)のジクロロメタン (4 mL, 0.5 mol/L)溶液に トリエチルアミン (0.416 mL, 3.0 mmol)， (362 mg, 2.4 mmol)を加えた後、さらに DMAP (24.4mg, 0.20 mmol)を加え、室温で1.5時間撹拌した。 飽和炭酸水素ナトリウム水溶液 (10 mL)、ジクロロメタン (10 mL)を加えて反応停止した後、反応溶液をジクロロメタン (5 mL x 3)で抽出した …

To a solution of the SM (1.2 g, 3.4 mmol), imidazole (0.70 g, 10 mmol), and dry DCM (33 mL) was added TBSCl (0.77 g, 5.1 mmol) under N2 at RT. The reaction mixture was stirred at RT for 75 min. The mixture was quenched with H2O and extracted with DCM.

tert-Butyldimethylsilylchlorid (kurz: TBDMSCl; oft auch weiter verkürzend TBSCl) ist eine chemische Verbindung, die dazu dient, TBS- Schutzgruppen einzuführen. Eine einfache Laborsynthese von tert -Butyldimethylsilylchlorid ist die Reaktion von tert …