2024年12月25日 · TBX3 (T-Box Transcription Factor 3) is a Protein Coding gene. Diseases associated with TBX3 include Ulnar-Mammary Syndrome and Holt-Oram Syndrome. Among its related pathways are MITF-M-dependent gene expression and Nervous system development.

T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene. [1] [2]T-box 3 (TBX3) is a member of the T-box gene family of transcription factors which all share a highly conserved DNA binding domain known as the T-box.The T-box gene family consists of 17 members in mouse and humans that are grouped into five subfamilies, namely Brachyury (T), T-brain (Tbr1), TBX1 ...

TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family, is a critical developmental regulator of several structures including the heart, mammary glands, limbs and lungs. Indeed, mutations in the human TBX3 lead to ...

2025年1月6日 · We found that TBX3 is primarily expressed in malignant cells, where TBX3 high tumor cells increase the secretion of TGFβ1, which promotes the infiltration of cancer-associated fibroblasts (CAFs), thereby forming an immunosuppressive microenvironment. We further demonstrated that TBX3 enhances TGFβ1 expression by binding to the TGFβ1 promoter ...

In this study we generated TBX3 over-expressing and TBX3 knockdown human ESC lines to investigate the role of TBX3 in regulating human ESC self-renewal and differentiation. In contrast to mouse ESC studies, we found that neither over-expression nor knockdown of TBX3 was able to attenuate self-renewal ability to induce differentiation in ...

The T-box transcription factor Tbx3 plays multiple roles in normal development and disease. In order to function in different tissues and on different target genes, Tbx3 binds transcription factors or other cofactors specific to temporal or spatial ...

TBX3 Promotes Cervical Cancer Proliferation and Migration via HPV E6 and E7 Signaling. TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration. TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and …

2024年10月28日 · Title: Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset. TBX3 activating PVT1 accelerates proliferation, migration, and invasion by modulating the miR-30a/LOX axis in anaplastic thyroid carcinoma.

2021年2月21日 · TBX3 is a liver-specific target of the Wnt/β-catenin pathway and thought to be an oncogene in promoting liver cancer development. Herein, we demonstrate that TBX3 is in fact a tumor suppressor gene that restricts liver tumor growth. Strategies which increase TBX3 expression and/or activities may be …

2020年2月5日 · TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family, is a critical developmental regulator of several structures including the heart, mammary glands, limbs and lungs.