2013年5月1日 · We demonstrate that Id2 restrains CD8(+) T cell memory differentiation by inhibiting E2A-mediated direct activation of Tcf7 and that Id2 expression level mirrors T cell memory recall capacity. As a result of the defective effector differentiation, Id2-deficient CD8(+) T cells fail to induce sufficient Tbx21 expression to generate short-lived ...

T cell factor 1 (Tcf1, encoded by Tcf7) is the key transcription factor of the canonical Wnt signaling pathway (Figure 1A). The Wnt signaling pathway is evolutionarily conserved and regulates a variety of fundamental processes such as development, cell-fate specification, and maintenance of tissue homeostasis.

2013年5月1日 · Tcf7, a critical regulator of memory CD8 + T cell differentiation, persistence, and recall potential , was significantly upregulated in Id2-deficient CD8 + T cells and correlated with the dose of Id2 . Tcf7 expression was also downregulated in Id2-deficient T …

2024年1月29日 · In the present study, we show that inhibitor of DNA binding protein 2 (Id2) transcriptionally and epigenetically promotes the generation of Slamf6 + Tex prog cells and their conversion to Tex...

2020年8月20日 · INs-seq profiling of the TFs TCF7, ID2, and TCF7 and ID2 double-positive populations shows the potential of the technology to define new T cell subsets. Finally, we focus on characterizing MDSCs based on their metabolic features to reveal their cellular and molecular profile in the TME and identify markers and pathways specific for MDSCs.

2016年10月4日 · Tcf7 and Id2 were both strongly induced in the αLP, whereas ID2 expression was maintained in ILC2p, but Tcf7 expression was downregulated (Figure 4 A). These data suggest that each of these factors play an important role …

id2+门具有cd 8 t细胞效应功能，效应细胞占id2门的93%，其富集率是cd45免疫种群的11倍（fig.3g-j）。 TCF7 + ID2 + DP门定义了特征较少的 T细胞亚群 ，并特别富集了中央记忆（CM）的两种细胞状态和效应记忆（EM）T细胞的一种状态（Fig.3H）。

Genetic deletion of Id2 dampens CD8 + T-cell-mediated immune responses and the maintenance of stem-like CD8 + T-cell subpopulations, suppresses PD-1 blockade and increases tumor susceptibility. Mechanistically, through its HLH domain, Id2 binds and disrupts the assembly of the Tcf3-Tal1 transcriptional regulatory complex, and thus modulates ...

2020年8月24日 · This included genes involved in memory development such as Tcf7 and Bach2, as well as genes implicated in effector differentiation and function including Id2 and Gzmb, and exhaustion such as ...

2013年5月1日 · We demonstrate that Id2 restrains CD8 + T cell memory differentiation by inhibiting E2A-mediated direct activation of Tcf7 and that Id2 expression level mirrors T cell memory recall capacity. As a result of the defective effector differentiation, Id2-deficient CD8 + T cells fail to induce sufficient Tbx21 expression to generate short-lived ...