TEAD proteins are found in many organisms under different names, assuming different functions. For example, in Saccharomyces cerevisiae TEC-1 regulates the transposable element TY1 and is involved in pseudohyphale growth (the elongated shape that yeasts take when grown in nutrient-poor conditions). [ 21 ]

2021年6月15日 · The most well-known role of TEADs involves the regulation of progenitor proliferation, stem cell identity, and lineage specification. TEAD factors also control tissue size and function by coupling external cytoarchitectural signals to cell growth and specification.

Transcriptional enhanced associate domain (TEAD) transcription factors play important roles during development, cell proliferation, regeneration, and tissue homeostasis. TEAD integrates with and coordinates various signal transduction pathways ...

2024年12月25日 · TEAD1 (TEA Domain Transcription Factor 1) is a Protein Coding gene. Diseases associated with TEAD1 include Sveinsson Chorioretinal Atrophy and Soft Tissue Sarcoma.Among its related pathways are Gene expression (Transcription) and ERK Signaling.Gene Ontology (GO) annotations related to this gene include DNA-binding …

The TEAD family of transcription factors is necessary for developmental processes. The family members contain a TEA domain for the binding with DNA elements and a transactivation domain for the interaction with transcription coactivators.

There are 4TEAD (TEAD1–4) genes in mammals which may have redundant or non-redundant functions depending on specific cell/tissue and developmental context (Lin et al., 2017).

2 天之前 · TEAD-driven transcriptional programs upregulate anti-apoptotic factors such as BIRC5 (survivin), enhancing cell survival and resistance to programmed cell death. This oncogenic potential has made TEAD a target for therapeutic interventions, with efforts underway to develop small-molecule inhibitors that disrupt its interaction with YAP/TAZ ...

There are four human genes that encode TEA domain transcription factors, TEAD1-4. The TEAD TFs bind to YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) proteins, which are downstream effectors of Hippo pathway signalling.

2023年1月26日 · TEAD (TEA/ATTS domain) proteins are evolutionarily conserved transcription factors [1,2]. TEAD1–4 in mammals and Scalloped in Drosophila have been the most studied. TEADs were initially identified as factors occupying the enhancer region of the SV40 virus as well as promoters and enhancers of muscle-specific genes . The TEAD-binding motif has ...

2020年6月23日 · Using a variety of biochemical, structural, and cellular methods, we uncover that TEAD S-palmitoylation functions as a TEAD homeostatic protein level checkpoint and that dysregulation of this lipidation affects TEAD transcriptional activity in a …