2024年12月25日 · This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor.

Transcriptional enhancer factor TEF-1 also known as TEA domain family member 1 (TEAD1) and transcription factor 13 (TCF-13) is a protein that in humans is encoded by the TEAD1 gene. [ 5 ] [ 6 ] [ 7 ] [ 8 ] TEAD1 was the first member of the TEAD family of …

哺乳动物TEAD蛋白家族有4种 (TEAD1-4)，分别由四种不同基因编码。 TEAD1-4功能不尽相同，但是几乎所有的组织至少表达其中一种蛋白。 结构上，TEADs包含N-端DNA结合域 (DBD)和C-端YAP结合域，两个结构域由约90-100个氨基酸残基长度的序列连接。 TEAD1-4蛋白异构体中，DBD和YBD高度保守 (>90%)，而连接序列同源度很低。 TEADs-YAP晶体复合物显示，TEADs的YBD 结构域表面上存在三个高度保守的结合位点 (site 1, 2 和 3)，其中site 3 是 …

2021年6月15日 · As transcription factors, TEADs orchestrate gene transcription to guide development (Landin-Malt et al., 2016). The most well-known role of TEADs involves the regulation of progenitor proliferation, stem cell identity, and lineage specification.

TEAD proteins constitute a family of highly conserved transcription factors, characterized by a DNA-binding domain called the TEA domain and a protein-binding domain that permits association with transcriptional co-activators. TEAD proteins are unable to …

2020年3月13日 · Hippo signaling regulates gene expression through Tead transcription factors (TFs). We show that Hippo transcriptional coactivators Yap1/Taz and the Teads have distinct functions during...

Nuclear protein interactions involving TEADs influence the transcriptional regulation of genes involved in cell growth, tissue homeostasis, and tumorigenesis. Clearly, protein interactions for TEADs are functionally important, but the full repertoire of …

2017年11月1日 · TEADs are the primary transcription factors for the YAP/TAZ transcription coactivators of the Hippo pathway. TEADs play an important role in development, tissue homeostasis, and tumorigenesis through regulation of processes such as cell growth and proliferation, differentiation, and survival.

2017年12月18日 · Transcriptional enhanced associate domain (TEAD) proteins are the downstream effectors of the Hippo signaling pathway that regulate cell proliferation and stem cell functions. TEADs are unable to activate transcription and require the help of coactivators such as YAP, TAZ, VgLL, and p160 proteins.

2016年10月10日 · TEAD proteins constitute a family of highly conserved transcription factors, characterized by a DNA-binding domain called the TEA domain and a protein-binding domain that permits association with transcriptional co-activators. TEAD proteins are unable to induce transcription on their own.