2000年4月1日 · Our data suggest that eotaxin, eotaxin-2, MCP-4, and RANTES induce eosinophil TEM via CCR3 with varied potency and efficacy. Activation of HUVEC by IL-1β or TNF-α or priming of eosinophils by IL-5 both promote CCR3-dependent migration of eosinophils from the vasculature in conjunction with CCR3-active chemokines.

2004年10月15日 · Because transendothelial migration (TEM) represents an essential step for extravasation of cells, for the first time we have studied basophil TEM using HUVEC. Treatment of HUVEC with IL-1β significantly enhanced basophil TEM, which was further potentiated by the presence of a CCR3-specific ligand, eotaxin/CCL11.

The HUVEC model has been particularly useful in the study of the effects of hemodynamic forces on the endothelium and atherosclerotic plaque formation, since the model allows to expose EC to shear stress controlling flow conditions, and thus, mimicking blood flow conditions in vivo [5].

2012年10月1日 · In this model, human peripheral blood mononuclear cells (PBMC) are placed on the apical surface of the HUVEC, followed by brief (30 min to 2 h) incubation in which monocytes selectively undergo apical-to-basal (forward) TEM into the collagen beneath, most likely due to constitutive production of chemokines such as CCL2 by the HUVEC (Muller and ...

人脐静脉内皮细胞（英Human Umbilical Vein Endothelial Cells，HUVEC）在进行血管内皮细胞实验时，通常选用的细胞模型为人脐静脉内皮细胞（Human umbilical vein endothelial cells，简称HUVECs）。 而不是直接采用静脉血管内皮细胞或动脉血管内皮细胞。

This detailed review summarizes the ultrastructural features of HUVECs and highlights the utility of TEM as a pivotal tool for analyzing HUVECs in diverse research frameworks, contributing valuable insights into the comprehension of HUVEC behavior and enriching our knowledge into the complexity of vascular biology.

2002年6月15日 · I-TAC induced a marked (4- to 6-fold) increase in transendothelial migration (TEM) of T cells across unstimulated HUVEC from 5.6 to 28% of input T cells and was substantially more active than IFN-γ-inducible protein-10, another CXCR3 ligand.

目前市面上主要有两种人脐静脉内皮细胞，一种是原代细胞，英文缩写为HUVEC，另一种是有限传代细胞系，英文缩写为HUV-EC-C。 该细胞可用于心血管疾病的研究，常见于研究低氧、炎症、 氧化应激 、感染反应以及肿瘤相关血管生成等应用中。 原代细胞——HUVEC

人脐静脉内皮细胞 （HUVEC）是体外研究内皮细胞过程最常用的细胞类型。 海星生物提供的脐静脉内皮细胞系 (HUVEC细胞系)取自自然分娩、健康的新生儿脐带组织经 SV40T转化，具有良好的传代能力及性状表现。

2024年5月1日 · To overcome this, we fused RAW264.7 macrophage membranes with human umbilical vein endothelial cell (HUVEC) membranes to prepare hybrid extracellular vesicles (RAW-HEVs) consisted of both types of cell membrane proteins. This hybrid EVs exhibited high uptake ratio towards LPS-induced inflammatory HUVECs and H9C2 cells.