Central memory T (Tcm) cells are the longest-lived, whereas effector memory T (Tem) 6 and terminal effector memory T (Ttem) cells have more potent cytotoxic activity but have a terminal fate. 12,13 While multiple molecular players in the differentiation process of memory CD8 + T cells have been identified, efforts continue to identify the cell-e...

A prion (/ ˈ p r iː ɒ n / ⓘ) is a misfolded protein that induces misfolding in normal variants of the same protein, leading to cellular death. Prions are responsible for prion diseases, known as transmissible spongiform encephalopathy (TSEs), which are fatal and transmissible neurodegenerative diseases affecting both humans and animals.

Here we report a near-atomic core structure of a brain-derived, fully infectious prion (263K strain). Cryo-electron microscopy showed amyloid fibrils assembled with parallel in-register intermolecular β sheets. Each monomer provides one rung of the ordered fibril core, with N-linked glycans and glycolipid anchors projecting outward.

2019年8月6日 · Prion diseases are caused by the conversion of physiological PrP C into the pathogenic misfolded protein PrP Sc, conferring new properties to PrP Sc that vary upon prion strains. In this work,...

Prion diseases (PrD) or transmissible spongiform encephalopathies (TSE) are invariably fatal and pathogenic neurodegenerative disorders caused by the self-propagated misfolding of cellular prion...

2020年6月8日 · Negative-staining transmission electron microscopy (TEM) imaging showed that recombinant, full-length PrP C formed homogeneous and unbranched fibrils (Fig. 1a). Congo red...

Transmissible spongiform encephalopathies (TSEs) are epidemic neurodegenerative diseases caused by prion proteins; in particular, they are induced by misfolded prion...

2024年12月20日 · Here, we studied how prion infection in mice disrupts the synaptic function in three limbic regions, the hippocampus, hypothalamus, and amygdala, at a pre-clinical stage (mid-incubation period) and early clinical onset.

2023年6月21日 · Prion diseases comprise a singular group of neurodegenerative conditions caused by endogenous, misfolded pathogenic (prion) proteins, associated with molecular aggregates. In humans, classical prion diseases include Creutzfeldt–Jakob disease, fatal familial insomnia, Gerstmann–Sträussler–Scheinker syndrome, and kuru.

2023年1月16日 · Transmissible spongiform encephalopathies (TSEs) or prion diseases are invariably fatal neurodegenerative disorders affecting mammals and include...