2016年11月10日 · We developed fully biodegradable/metabolizable nanosystem based on polymer surfactant-stabilized thermoresponsive solid lipid nanoparticles with non-covalently bound photosensitizer temoporfin (T-SLNP) with particle size below 50 nm.

This study investigated a solid lipid nanoparticle (SLNP) system’s ability to bind and safely deliver siRNA in vitro. SLNPS were formulated using sphingomyelin and cholesterol, with Ginkgo biloba leaf extract (GBE) incorporated to enhance biocompatibility and neuroprotection.

2023年11月1日 · In this study, glioma cell membranes are used to encapsulate indocyanine green (ICG) loaded nanoparticles (SLNP/ICG), termed as SLNP/ICG@M for targeted photodynamic therapy (PDT) against glioma. Cell membrane modification significantly enhances cellular uptake of SLNP/ICG@M in homologous glioma cells in vitro and tumor distribution in vivo.

2025年1月10日 · In the present study, we constructed a tandem CRISPR/Cas13d system cleaving the conserved regions of the polymerase acidic (PA), nucleoprotein (NP), and matrix (M) gene segments of IAV and delivered this CRISPR/Cas13d system by lipid nanoparticles (LNPs), which target cells with IAV receptors (Figure 1), and we named this drug sLNP(CRI). sLNP ...

Visualize mRNA-loaded (left) and unloaded (right) lipid nanoparticle samples with cryo-TEM imaging. Cryotransmission electron microscopy (cryo-TEM) has long played a pivotal role in the characterization of lipid nanoparticles.

2025年2月8日 · Transmission electron microscopy (TEM) images further demonstrated homogeneous spherical nanoparticles in both sLNPs-OVA and sLNPs-OVA/Cel formulations (Figure S1B, Supporting Information). Next, we investigated the impact of celastrol on mRNA translation efficiency using the tolerogenic mRNA-LNPs vaccine platform, substituting OVA-mRNA with ...

Tumor‐associated macrophages (TAMs)—representative immune‐suppressive cells in the tumor microenvironment (TME)—are known to promote tumor progression and metastasis,...

2021年10月4日 · The physicochemical characterization of BSE loaded solid lipid nanoparticles (BSE-SLNp) has been analyzed using Zetasizer, FT-IR, and TEM. The BSE-SLNp showed an average diameter of 20–110 nm on the day of preparation and …

SLNPs were successfully prepared with smaller particle size of 67.63 ± 5.02 nm, higher DL% of 5.58 ± 0.41% and PDI of 0.159 ± 0.018 ( Fig. S1 and Table S1). The particle size and TEM image of...

2020年10月27日 · In this study, the “cell-chemotherapy” strategy was presented to enhance antitumor efficacy. M1-type macrophages, which are therapeutic immune cells with both of immunotherapeutic ability and targeting ability, carried sorafenib (SF)-loaded lipid nanoparticles (M1/SLNPs) were developed.