Tenascin-C is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest ; it is also abundant in developing tendons , bone and cartilage . Tenascin-R is found in the developing and adult nervous system.

2024年12月25日 · TNC (Tenascin C) is a Protein Coding gene. Diseases associated with TNC include Deafness, Autosomal Dominant 56 and Rare Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna . Among its related pathways are …

2016年12月1日 · Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that …

Tenascin-C, -R, -X and -W are the four members of a family of large, multimodular, extracellular matrix molecules. By virtue of a large repertoire of binding partners, including other matrix molecules, soluble factors, and cell surface receptors, tenascins are key regulators of both tissue architecture and cell phenotype.

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair.

Tenascins are a family of large extracellular matrix (ECM) glycoproteins with 4 known members in vertebrates: tenascin-W, tenascin-C, tenascin-X and tenascin-R (TN-R). The discovery of TN-R was a multistep process.

2025年1月10日 · Here, the extracellular matrix (ECM) tenascin-C (TNC) is found to express in the periosteum and recruit inflammatory macrophages. TNC-deficiency in the periosteum delays bone repair.

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C ...

Tenascins are a family of large multimeric extracellular matrix (ECM) proteins. Vertebrates express four tenascins termed tenascin-C, -R, -X and -W present in their connective tissues. Each tenascin has a specific expression pattern. To the contrary …

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and …