Several randomized controlled trials (RCTs) have compared tenecteplase to alteplase for treatment of acute ischemic stroke (AIS). Yet, there is no meta-analysis that includes the latest published RCTs of 2022.

2024年10月16日 · We conducted an updated systematic review and meta-analysis including all available RCTs that investigated efficacy and safety of TNK 0.25 mg/kg compared with TPA for the treatment of AIS within 4.5 hours of onset.

Tenecteplase is a bioengineered variant of the tissue plasminogen activator alteplase, whereby the alteplase protein structure is modified at 3 sites (T103N, N117Q, KHRR 296-299 AAAA), resulting in a higher fibrin specificity and a longer half-life, allowing administration as a single intravenous bolus. 9,10 Tenecteplase is globally licensed as ...

2018年4月25日 · We conducted the Tenecteplase versus Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK) trial to compare tenecteplase with alteplase in establishing reperfusion in...

2024年4月26日 · Tenecteplase, a modified form of alteplase using recombinant technology, has several pharmacological advantages over alteplase, including longer half‐life, higher fibrin specificity, and greater resistance to plasminogen activator inhibitor‐1.

2022年1月4日 · This systematic review compares the efficacy of tenecteplase vs. alteplase with regard to three outcomes: (1) rate of symptomatic hemorrhage, (2) functional outcome at 90 days, and (3) reperfusion grade after thrombectomy to compare the efficacy of both thrombolytics in AIS

2021年2月16日 · Tenecteplase is a modified recombinant tissue-type plasminogen activator molecule that has a number of hypothetical advantages over alteplase, including longer half-life, greater fibrin specificity, and lesser likelihood of fibrinogen depletion.

2024年11月5日 · Importance: Tenecteplase is a bioengineered variant of alteplase with greater fibrin specificity and a longer half-life, allowing single-bolus administration. Evidence on the treatment effect of tenecteplase 0.25 mg/kg in Chinese patients …

Tenecteplase has potential benefits over alteplase, the standard agent for intravenous thrombolysis in acute ischaemic stroke, because it is administered as a single bolus and might have superior efficacy. The ATTEST-2 trial investigated whether tenecteplase was non-inferior or superior to alteplase within 4·5 h of onset.

2024年11月12日 · Background and objectives: The current European Stroke Organisation expedited recommendation on tenecteplase (TNK) for acute ischemic stroke (AIS) advocates that TNK 0.25 mg/kg can be used alternatively to alteplase (tissue plasminogen activator [TPA]) for AIS of <4.5 hours duration, based on a meta-analytical approach establishing noninferiority.