2021年2月24日 · Our study revealed the wide-spread situation of plasmid-borne tet (A) gene in clinical CRKP, and mutation of tet (A) is a potential driven force that lead to tigecycline resistance. Keywords: Klebsiella pneumoniae; mutation; plasmid-bearing; tet (A); tigecycline.

The meaning of TÊTE-À-TÊTE is a private conversation between two persons. How to use tête-à-tête in a sentence.

2021年2月23日 · Our study revealed the wide-spread situation of plasmid-borne tet (A) gene in clinical CRKP, and mutation of tet (A) is a potential driven force that lead to tigecycline resistance. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is currently a substantial threat to public health worldwide.

Five common tetracycline resistance genes tet(A), tet(B), tet(M), tet(O) and tet(S) were studied by polymerase chain reaction in 100 bacteria isolated from Iranian fish farms. In the antibiogram test most of the bacteria were either intermediately or completely resistant to tetracycline.

外排是四环素抗性的最常见机制。通常在肠杆菌科中普遍流行的A类四环素外排泵由tet（A）和tet（A）-1基因编码。这些基因具有两个潜在的起始密码子，即GTG和ATG，位于该基因的上游。

TÊTE-À-TÊTE翻译：两人密谈;（尤指朋友间的）促膝谈心, 两人私下地;亲密地。 了解更多。

2023年9月5日 · 近日，我院杜向党教授团队在临床分离的碳青霉烯耐药肺炎克雷伯氏菌（CRKP）中发现了一种可介导替加环素高耐药表型的机制，其由 tet (A)v的扩增引起，该成果以Emergence of high-level tigecycline resistance due to the amplification of a tet (A) gene variants in c

2024年6月3日 · Tigecycline resistance is due to the tandem amplification of a ΔTnAs1-flanked tet (A)TIG-carrying plasmid-borne segment in E. coli. The gain/loss of the tandem amplificates in the presence/absence of tigecycline represents an economic way for the bacteria to survive in the presence of tigecycline.

2024年11月24日 · 替加环素是继米诺环素后开发的新一代四环素类抗生素，通过可逆结合细菌核糖体30S亚基，阻断tRNA进入核糖体A位点来抑制蛋白质合成，达到抗菌目的 [3]。 其与核糖体的亲和力比四环素高十几倍，具有更高的抗菌活性。 作为治疗多重耐药肺炎克雷伯氏菌感染的重要敏感储备药物，其耐药机制备受国内外关注。 本实验从临床分离到一株替加环素耐药的肺炎克雷伯氏菌，利用电转化、酶切、克隆、测序分析、药敏实验等方法，对其耐药机制进行研究。 结果证 …

2018年5月7日 · 本实验从临床分离到1株替加环素耐药肺炎克雷伯氏菌,电转化实验获得了一个对替加环素耐药的质粒,功能性分析发现该质粒中的 tet (A)基因发生了双移码突变,且药敏实验证实这些突变可单独使替加环素的MIC值增加8倍,米诺环素和四环素的MIC值增加128倍。 研究证实,质粒介导的 tet (A)突变体可导致肺炎克雷伯氏菌对替加环素耐药,扩宽了对肺炎克雷伯氏菌替加环素耐药机制的认识,并为该类型耐药基因在革兰氏阴性菌中的扩散控制提供了依据。 关键词: 替加环素, …