Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation , [ 5 ] [ 6 ] but is expressed as ...

人tet蛋白家族有三个成员，分别为tet1、tet2和tet3，tet1是在研究一例存在t(10；11)（q22；q23）异位的 白血病 患者时鉴定成功的，因此得名。 TET2和TET3则是在胎儿大脑 cDNA文库 中克隆成功。

2024年12月25日 · TET1 (Tet Methylcytosine Dioxygenase 1) is a Protein Coding gene. Diseases associated with TET1 include Hypoascorbemia and Leukemia. Among its related pathways are Gene expression (Transcription) and Epigenetic regulation by …

The full-length canonical TET1 isoform appears virtually restricted to early embryos, embryonic stem cells and primordial germ cells (PGCs). The dominant TET1 isoform in most somatic tissues, at least in the mouse, arises from alternative promoter usage which gives rise to a short transcript and a truncated protein designated TET1s.

2023年8月11日 · Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield...

2025年2月8日 · TET1 contributes to the activation of macrophages through transcriptional activation of TNFalpha gene. TET1 promotes stemness properties, and inhibits EMT, in HSIL cells, through 5hmC-dependent and -independent mechanisms.

DNA 甲基化是一种表观遗传机制，对控制基因表达很重要。 该基因编码的蛋白质是一种属于 TET (十-十一易位) 家族的去甲基化酶。 TET 蛋白家族的成员在 DNA 甲基化过程和基因激活中发挥作用。 [RefSeq 提供，2015 年 9 月] DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family.

2010年11月16日 · In summary, features within the TET1 C-terminal domain strongly suggest that TET1 may function as a non-heme iron-dependent dioxygenase, and features of its N-terminal CXXC domain predict a...

2025年1月4日 · By removing methyl groups from specific tumor suppressor genes, TET1 can influence their expression. This review summarizes the latest advancements in TET1 research, emphasizing its role in demethylation mechanisms and its significance in regulatory processes related to clinical conditions.

2025年2月8日 · Tet1-mediated 5hmC regulates hippocampal neuroinflammation via wnt signaling as a novel mechanism in obstructive sleep apnoea leads to cognitive deficit. TET1 promotes RXRalpha expression and adipogenesis through DNA demethylation. TET1 displays catalytic and non-catalytic functions in the adult mouse cortex.