Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation , [ 5 ] [ 6 ] but is expressed as ...

2024年12月20日 · Here, we profile 5-methylcytosine (5m C)-oxidising Ten-Eleven Translocation (TET) enzymes using MS and 1 H NMR spectroscopy methods and reveal a high degree of substrate oxidation-independent 2OG...

2023年8月11日 · Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield...

The ten–eleven translocation (TET) family of dioxygenases consists of three members, TET1, TET2, and TET3. All three TET enzymes have Fe+2 and α-ketoglutarate (α-KG)-dependent dioxygenase activities, catalyzing the 1st step of DNA demethylation by ...

2018年2月16日 · We conclude that Tet1 activity, determined by [O2] may play a critical role in regulating cellular differentiation and fate in embryogenesis. Graded levels of molecular oxygen (O2) exist within developing mammalian embryos and can differentially regulate cellular specification pathways.

本文介绍了双加氧酶TET1的结构和去甲基化作用的机制，综述了其在胚胎发育、免疫应答、干细胞调控、癌症发展和神经系统发育等过程中发挥表观遗传调控作用的研究现状，并简述了其上游调控机制，为相关领域的深入研究提供了新的思路。 1. College of Veterinary Medicine, Southwest University, Chongqing 402460, China 2. Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China.

DNMT1是维持性DNA甲基转移酶,广泛分布于各种组织中,它更偏好作用于半甲基化的CpG位点,在细子(young retrotransposons)启动子区域建立甲基化,这一特定的甲基转移酶活性对小鼠的生育能力至关重要[6] 。 然而,研究人员对于DNMT3C的活性及功能还存在争议,有待进一步分析。 DNA甲基化是一种稳定的修饰,然而,它在生物体内并不是一成不变的。 哺乳动物的个体发育过程中,基因组的甲基化谱式会经历两次大规模的重编程过程[7-8]。 第一次去甲基化发生在配子形成过程中,原始 …

2017年8月14日 · In this study, we sought to elucidate the biological function and mechanism of TET1 in trophoblast cells exposed to 3% O 2. We compared TET1 expression in villi and term placentas. Using a...

DNA 甲基化是一种表观遗传机制，对控制基因表达很重要。 该基因编码的蛋白质是一种属于 TET (十-十一易位) 家族的去甲基化酶。 TET 蛋白家族的成员在 DNA 甲基化过程和基因激活中发挥作用。 [RefSeq 提供，2015 年 9 月] DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family.

2025年2月8日 · Tet1 overexpression affected adult neurogenesis with oligodendrocyte differentiation in the hippocampal dentate gyrus of Tet1-TG mice. In addition, Tet1 overexpression induced the elevated expression of immediate early genes, such as Egr1, c-fos, Arc, and Bdnf, followed by the activation of intracellular calcium signals in prefrontal and ...