The expression of TfR1 is regulated post-transcriptionally by the IRE–IRP system and is inversely correlated with cellular iron status; TfR1 expression is high during iron deficiency, whereas high iron leads to lower TfR1 expression (Casey et al. 1988; Anderson et al. 2012; Kühn 2015).

铁调节蛋白（iron regulatory protein，IRP）可以在转录后水平调节铁蛋白及转铁蛋白的表达来调控细胞的铁代谢。 尽管IRP1和IRP2都可以激活铁-饥饿应答，但据报道IRP1可以直接感知铁硫簇缺乏来激活这种反应，所以作者选择先探究上述的过程是否依赖于IRP1。

As iron deficiency drives TfR1 mRNA stabilization rather than degradation via the IRP–IRE system, the role of Reg1 in TfR1 mRNA destabilization may not be necessarily associated with the IRP–IRE system.

Circulating, holo-Tf binds to the cell-surface transferrin receptor-1 (TfR1) and is endocytosed. Through an endocytic process known as the Tf cycle, the iron is released from Tf and is taken up into the cell.

Cellular iron homeostasis is accomplished by the coordinated regulated expression of the transferrin receptor and ferritin, which mediate iron uptake and storage, respectively. The mechanism is posttranscriptional and involves two cytoplasmic iron …

2012年9月1日 · Tf-Fe (III) binds to cell surface transferrin receptor 1 (TFRC, also known as TfR1) followed by internalization of the Tf-Fe (III)–TfR1 complex by clathrin-mediated endocytosis. On acidification of the endosome, ferric iron is released from Tf and reduced by STEAP3, and exported into the cytosol by DMT1.

最新研究发现曲贝替丁在NSCLC细胞中通过HIF-1α/IRP1 轴上调的TFR1 诱导铁下垂[10] 。 曲贝替丁作用于HIF-1α/IRP1 轴,使TFR1升高,促进铁吸收;铁依赖性性活性氧(ROS) 水平和脂质过氧化物升高[19] ,再加上GPX4下调共同导致铁下垂[20] ,从而杀死NSCLC 细胞。 依赖HIF-1α/IRP1 轴上调 …

IRE binding by IRPs enhances iron uptake through the upregulation of TfR1 and DMT1. IRPs also repress the expression of both subunits of ferritin (ferritin light chains and FTH1), decreasing iron storage and promoting ferritinophagy, and also diminishes ferroportin-1 expression, the unique transporter that allows iron export from cells.

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in …

2014年7月28日 · Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism. The mechanism involves their binding to iron responsive elements (IREs) in the untranslated regions of target mRNAs, thereby controlling mRNA translation or stability.