2021年1月1日 · In this study, we aimed to investigate the specific role of mitochondrial ROS (mtROS) in initiating mitochondrial DNA (mtDNA) damage and inflammation during IRI-AKI. Methods: The changes in renal function, mitochondrial function, and inflammation in IRI-AKI mice with or without mtROS inhibition were analyzed in vivo.

Mitochondrial metabolic dysfunctions induced by insulin resistance are linked to abnormal Ca 2+ flux and high reactive oxygen species (ROS) levels. The metabolic functions that regulate Ca 2+ flux are also associated with glucose uptake and metabolism .

2020年7月15日 · MdTFAM is a potential biomarker for oxidative stress. Mitochondrial transcription factor A (TFAM) plays a key role in regulating the transcription, replication, and maintenance of mitochondrial DNA. In the present study, a Musca domestica TFAM (MdTFAM) gene was identified and characterized.

2024年5月23日 · We discovered that mitochondrial transcription factor A (TFAM)—a protein that binds mitochondrial DNA (mtDNA)—helps to eliminate leaked mtDNA by interacting with the autophagy protein LC3 through...

2021年1月1日 · In this study, we aimed to investigate the specific role of mitochondrial ROS (mtROS) in initiating mitochondrial DNA (mtDNA) damage and inflammation during IRI-AKI. Methods: The changes in renal function, mitochondrial function, and inflammation in IRI-AKI mice with or without mtROS inhibition were analyzed in vivo.

mtROS 通过抑制其转录和促进 Lon 介导的 TFAM 降解来减少 HK2 细胞中线粒体 TFAM 的丰度。TFAM 的沉默消除了氧化应激下 HK2 细胞中线粒体功能和细胞因子释放的 Mito-Tempo (MT) 诱导的拯救。在 IRI-AKI 小鼠和 AKI 患者的肾脏中发现了 TFAM 丢失和 mtDNA 损伤。

2018年9月21日 · Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics. Oncotarget 7 , 11609–11624...

2018年1月5日 · Neonatal Tfam inactivation by AAV9-cTnT-Cre caused progressive, lethal dilated cardiomyopathy. Remarkably, postnatal Tfam inactivation and disruption of mitochondrial function did not impair cardiomyocyte maturation. Rather, it elevated ROS production, activated the DNA damage response pathway, and decreased cardiomyocyte proliferation.

广州医科大学冯杜团队在Nature Cell Biology 在线发表题为“TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA”的研究论文，该研究表明TFAM是一种自噬受体，通过结合细胞质线粒体DNA来限制炎症。 该研究发现线粒体转录因子A (TFAM) -一种结合线粒体DNA (mtDNA)的蛋白质-通过自噬酶体途径 (称之为核吞噬)与自噬蛋白LC3相互作用，帮助消除泄漏的mtDNA。 TFAM包含一个称为LC3相互作用区 (LIR)基序的分子邮政编码， …

The inhibitory activity of TFAM to reduce NFAT4 pathological hypertrophy and ROS-driven MMP9 may delay the myocardium remodeling state, before becoming end-stage HF. TFAM overexpression protected the aortic banded myocardium from cardiac hypertrophy.