2024年5月23日 · In this Article, we identify the major mtDNA-bound protein TFAM as an autophagy receptor for nucleoid clearance. We demonstrate that TFAM interacts with microtubule-associated protein 1 light...

广州医科大学冯杜团队在Nature Cell Biology 在线发表题为“TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA”的研究论文，该研究表明TFAM是一种自噬受体，通过结合细胞质线粒体DNA来限制炎症。 该研究发现线粒体转录因子A (TFAM) -一种结合线粒体DNA (mtDNA)的蛋白质-通过自噬酶体途径 (称之为核吞噬)与自噬蛋白LC3相互作用，帮助消除泄漏的mtDNA。 TFAM包含一个称为LC3相互作用区 (LIR)基序的分子邮政编码， …

Cellular metabolism is important for regulatory T cell (Treg) homeostasis and function. Fu et al. show that mitochondrial transcription factor A (Tfam)-mediated mitochondrial respiration is critical for Treg maintenance in non-lymphoid organs and tissues in the steady state and in tumors.

2024年5月25日 · 5月23日，广东省蛋白质修饰与降解重点实验室PI冯杜教授团队在Nature Cell Biology发表了题为“TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA”的论文。...

Cellular metabolism is important for regulatory T cell (Treg) homeostasis and function. Fu et al. show that mitochondrial transcription factor A (Tfam)-mediated mitochondrial respiration is critical for Treg maintenance in non-lymphoid organs and tissues in the steady state and in tumors.

Interactions of mitochondrial proteins with mtDNA damage are critically important for repairing, regulating, and signaling mtDNA damage. Mitochondrial transcription factor A (TFAM) is a key player in mtDNA transcription, packaging, and maintenance.

2021年10月18日 · Mitochondrial transcriptional factor A (TFAM) acts as a key regulatory to control mitochondrial DNA (mtDNA); the impact of TFAM and mtDNA in modulating carcinogenesis is controversial. Current...

2024年5月23日，广州医科大学冯杜团队在 Nature Cell Biology 期刊发表了题为：TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA 的研究论文，报道了TFAM作为自噬受体介导胞质中线粒体DNA（mtDNA）的清除，进而限制炎症反应。

Tfam 是一个在核内的基因，编码线粒体转录因子A (TFAM), 可稳定线粒体DNA以及促进线粒体DNA的复制。 已有研究表明，在Treg中TFAM缺失可诱导自身免疫性疾病的发生。 本研究旨在探究小鼠T细胞中特异性缺失TFAM后引起的T细胞线粒体功能异常，对小鼠发生早衰以及多重疾病的影响及其机制。 02 主要发现. 1 小鼠T细胞特异性缺失线粒体转录因子A (TFAM)，导致T细胞线粒体功能失调，促进小鼠发生早衰； 2 T细胞TFAM特异性缺失的小鼠，会引发多种与衰老相关的 …

2007年2月1日 · Human TFAM has an ability to bind to DNA in a sequence-independent manner and is abundant enough to cover whole region of mitochondrial DNA, owing to which TFAM stabilizes mitochondrial DNA through formation of nucleoid and regulates (or titrates) the amount of mitochondrial DNA.