T follicular helper cells (Tfh) are a specialized subset of CD4 + T cells that were first identified in the human tonsil. They play a critical role in protective immunity helping B cells produce antibody against foreign pathogens.

Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high affinity antibodies and memory B cells.

Tfh cells are the CD4 + T cells specialized for helping B cells. Bcl6 was identified as the Tfh lineage defining transcription factor 10 years ago. Crotty reviews the extensive progress made in understanding Tfh cells since then, including surprising roles of Tfh cells in a range of diseases.

T follicular helper (Tfh) cells are a subset of CD4-positive T helper cells that are involved in the humoral response [1]. Tfh cells are found in secondary lymphoid tissues, including tonsils, spleen, and lymph nodes. The role of Tfh cells is to trigger germinal center (GC) B cells into antibody-secreting plasma and memory B cells [2,3].

2022年7月11日 · TFH cells are essential in sustaining protective antibody responses necessary for pathogen clearance in infection and vaccine-mediated protection.

2013年5月17日 · Long-lived humoral immunity depends on help provided by CD4+ T cells, namely T follicular helper (TFH) cells, which support the differentiation of antigen-specific B cells into memory and plasma...

2022年12月6日 · The identification of a T FH cell master regulator solidified the concept of a fifth T cell subset, linking BCL-6 function, T FH cell differentiation and T cell help to B cells in germinal...

2014年10月16日 · Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma 6 (Bcl6) and other transcription factors. This article reviews understanding of Tfh cell biology, including their differentiation, migration, transcriptional regulation, and …

T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLOs) where they provide help to B cells in germinal centers ...

2019年5月21日 · Helping B cells and antibody responses is a major function of CD4 + T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4⁺ …