TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand.

转化生长因子tgf-β的名称来源于其转化活性，根据不同的细胞系，当与egf一起施用或不需要添加egf时，可诱导细胞锚定非依赖性生长。最先被鉴定并分离的两种转化生长因子是tgf-α和-β（β1）。但是tgf-α属于egf家…

Transforming growth factor alpha (TGFα) is perhaps the best studied member of the EGF family. It was initially identified in the conditioned media of sarcoma cells through its ability to promote a transformation of normal cultured cells.

2019年5月21日 · 转化生长因子α(transforming growth factor alpha, TGF-α)属表皮生长因子(epithelial growth factor, EGF)家族, 是目前被广泛研究的表皮生长因子受体(epithelial growth factor receptor, EGFR)配体。通过配受体作用, TGF-α能够调节细胞增殖、分化, 在人体生长发育中起重要 …

Transforming growth factor α (TGF-alpha; TGF-α) is a mitogenic polypeptide member of the epidermal growth factor (EGF) family of cytokines. TGF-α is composed of 50 amino acids, and displays 35-40% homology with EGF which is the prototypic member of the EGF superfamily.

Transforming growth factor alpha (TGF alpha) is a 6 kDa polypeptide mitogen that interacts with the epidermal growth factor receptor and activates its intrinsic tyrosine kinase. The mature 50 amino acid TGF alpha is released from a 159 or 160 amino acid integral membrane glycoprotein precursor, deno …

2024年12月25日 · TGFA (Transforming Growth Factor Alpha) is a Protein Coding gene. Diseases associated with TGFA include Tooth Agenesis and Cleft Lip . Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway .

Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, highlighting what we consider important advances related to its function in normal and disease states.

Transforming growth factor alpha (TGF alpha) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGF alpha, like EGF, exerts its effect on cells through binding to the EGF-Receptor …

tgfα能够刺激神经细胞在受损的成人大脑中增殖。tgf-α在2001年被美国国家卫生研究院（nih）描述为：可作用于成体干细胞，从而使神经变性疾病恢复部分功能。